HitPredict

Interactor 1: NTRK1 (P04629)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Gene: NTRK1

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25921289
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 796 Hs			1 875
+	Hs
		384459 NTRK1_HUMAN (1-796): 0: 621: 100.00		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		125077 NTRK1_HUMAN (1-796): 0: 621: 100.00		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		385368 NTRK1_HUMAN (1-796): 0: 621: 100.00		NED4L_HUMAN (247-873): 0: 575: 22.52
+	Hs
		384958 NTRK1_HUMAN (1-796): 0: 621: 100.00		HERC4_HUMAN (157-875): 3.32e-179: 547: 27.46
+	Hs
		507904 FGFR1_HUMAN (195-794): 0: 545: 26.34		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		385681 NTRK1_HUMAN (1-796): 0: 621: 100.00		HERC5_HUMAN (153-873): 1.77e-175: 536: 23.20
+	Hs
		601478 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		609205 FGFR3_HUMAN (168-794): 3.98e-158: 481: 25.98		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Mm
		601625 FGFR2_MOUSE (195-794): 0: 548: 25.04		SMUF1_MOUSE (376-872): 4.45e-180: 538: 27.00
+	Dr
		1109027 FGR1A_DANRE (91-794): 7.36e-173: 519: 24.53		Q3KRP0_DANRE (278-873): 0: 565: 23.09
+	Hs
		601595 FGFR2_HUMAN (87-794): 5.67e-159: 484: 22.55		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		434157 RET_HUMAN (391-794): 3.5e-114: 374: 30.44		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		808060 EPHA5_HUMAN (409-788): 2.48e-111: 365: 30.36		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		435577 IGF1R_HUMAN (493-777): 6.97e-71: 255: 42.61		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		385087 NTRK1_HUMAN (1-796): 0: 621: 100.00		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		384887 NTRK1_HUMAN (1-796): 0: 621: 100.00		UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27
+	Hs
		994672 DDR1_HUMAN (507-778): 1.77e-67: 242: 45.49		ITCH_HUMAN (325-873): 0: 579: 24.78
+	Hs
		1072678 NTRK3_HUMAN (36-796): 1.63e-174: 525: 49.37		UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27