HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: PPIL3 (Q9H2H8)
Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3)
Gene: PPIL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	29568061, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 161
+	Hs
		385712 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		PPIL2_HUMAN (3-161): 1e-74: 233: 49.69
+	Hs
		385868 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		CWC27_HUMAN (3-161): 2.6e-74: 231: 46.25
+	Hs
		386392 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		PPIL1_HUMAN (2-152): 4.43e-77: 228: 48.34
+	Mm
		876557 LMNA_MOUSE (1-664): 2.56e-71: 245: 94.90		PPIL1_MOUSE (2-152): 3.8e-77: 228: 48.34
+	Dr
		74871 B3DKC5_DANRE (9-597): 1.57e-53: 196: 64.92		Q6IQJ6_DANRE (3-161): 3.12e-74: 232: 49.06
+	Hs
		634426 LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45		PPIL2_HUMAN (3-161): 1e-74: 233: 49.69
+	Hs
		634495 LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45		CWC27_HUMAN (3-161): 2.6e-74: 231: 46.25
+	Hs
		386016 LMNA_HUMAN (1-664): 1.26e-79: 267: 100.00		PPIL4_HUMAN (1-154): 8.62e-37: 133: 41.98
+	Hs
		634548 LMNB1_HUMAN (21-581): 1.2e-49: 184: 54.45		PPIL4_HUMAN (1-154): 8.62e-37: 133: 41.98