HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	29187402, 22907436
Identification Methods	pull down, affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 406
+	Hs
		387362 P53_HUMAN (1-393): 0: 619: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		386201 P53_HUMAN (1-393): 0: 619: 100.00		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		387188 P53_HUMAN (1-393): 0: 619: 100.00		RN138_HUMAN (31-190): 6.27e-46: 160: 18.68
+	Hs
		386071 P53_HUMAN (1-393): 0: 619: 100.00		RO52_HUMAN (33-392): 4.67e-43: 158: 13.14
+	Hs
		387147 P53_HUMAN (1-393): 0: 619: 100.00		COP1_HUMAN (40-326): 3.5e-39: 151: 18.31
+	Hs
		387379 P53_HUMAN (1-393): 0: 619: 100.00		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		386227 P53_HUMAN (1-393): 0: 619: 100.00		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		387560 P53_HUMAN (1-393): 0: 619: 100.00		TRI39_HUMAN (39-392): 2e-35: 138: 13.84
+	Hs
		175834 P73_HUMAN (13-362): 2.35e-166: 481: 39.74		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		749852 P63_HUMAN (28-363): 2.35e-145: 429: 42.11		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63