HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: KPCD (Q05655)
Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]
Gene: PRKCD

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15731106
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0035556 - intracellular signal transduction and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 676
+	Mm
		537688 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		KPCD_MOUSE (1-675): 0: 780: 90.52
+	Hs
		388384 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCE_HUMAN (16-665): 0: 680: 40.23
+	Mm
		537687 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		KPCE_MOUSE (16-665): 0: 678: 40.65
+	Mm
		554863 CRYAB_MOUSE (18-197): 2.31e-51: 165: 38.89		KPCE_MOUSE (16-665): 0: 678: 40.65
+	Hs
		388469 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		PKN2_HUMAN (17-667): 4.03e-161: 490: 28.83
+	Hs
		388255 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		AKT1_HUMAN (270-667): 1.98e-150: 446: 36.86
+	Mm
		537689 HSPB1_MOUSE (1-205): 5.78e-74: 223: 83.25		AKT1_MOUSE (242-667): 2.66e-150: 446: 34.47
+	Hs
		358932 CRYAA_HUMAN (21-195): 8.38e-54: 171: 38.42		AKT3_HUMAN (324-665): 8.42e-146: 434: 42.61
+	Mm
		682124 HSPB2_MOUSE (1-181): 3.51e-43: 144: 33.88		AKT1_MOUSE (242-667): 2.66e-150: 446: 34.47
+	Hs
		388151 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCB_HUMAN (124-287): 1.64e-44: 171: 42.07
+	Hs
		388146 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCG_HUMAN (129-355): 1.07e-42: 166: 29.75
+	Hs
		388210 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCA_HUMAN (128-353): 1.03e-42: 166: 31.20
+	Hs
		388280 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCI_HUMAN (59-270): 2.75e-35: 143: 19.54
+	Hs
		388395 HSPB1_HUMAN (1-205): 4.5e-80: 239: 100.00		KPCZ_HUMAN (66-231): 1.99e-35: 143: 19.19