Protein: LIFR
Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118)

Gene: LIFR
Organism: Homo sapiens
Interactions: 45
UniProt ID: P42702

Gene Ontology (top 5):
GO:0004896 - cytokine receptor activity
GO:0004923 - leukemia inhibitory factor receptor activity
GO:0005127 - ciliary neurotrophic factor receptor binding
GO:0005886 - plasma membrane
GO:0007166 - cell surface receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

578202

LIF
Leukemia inhibitory factor

5

2

Small-scale

0.912

High

686743

CNTF
Ciliary neurotrophic factor

3

3

Small-scale

0.853

High

567758

ONCM
Oncostatin-M

3

4

Small-scale

0.834

High

689983

CNTFR
Ciliary neurotrophic factor receptor subunit alpha

2

19

Small-scale

0.812

High

820516

IL6RB
Interleukin-6 receptor subunit beta

2

16

Small-scale

0.754

High

841612

HFE
Hereditary hemochromatosis protein

1

5

High-throughput

0.691

High

209212

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

4

High-throughput

0.618

High

362928

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

711051

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

18

Small-scale

0.618

High

841604

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

351667

SG1D1
Secretoglobin family 1D member 1

2

1

High-throughput

0.574

High

841618

TAFA4
Chemokine-like protein TAFA-4

2

4

High-throughput

0.574

High

159551

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

19

High-throughput

0.553

High

841626

FBX2
F-box only protein 2

2

14

High-throughput

0.549

High

841608

SLAF1
Signaling lymphocytic activation molecule

1

11

High-throughput

0.536

High

841611

CTF1
Cardiotrophin-1

1

3

High-throughput

0.536

High

841605

SC61B
Protein transport protein Sec61 subunit beta

2

1

High-throughput

0.533

High

841630

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

347563

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.489

High

639679

TAF1
Transcription initiation factor TFIID subunit 1

1

3

High-throughput

0.489

High

841614

TAFA2
Chemokine-like protein TAFA-2

1

4

High-throughput

0.489

High

841624

TF7L2
Transcription factor 7-like 2

1

1

High-throughput

0.489

High

841621

SORT
Sortilin

1

0

Small-scale

0.480

High

217926

TGON2
Trans-Golgi network integral membrane protein 2

1

9

High-throughput

0.479

High

841606

K22O
Keratin, type II cytoskeletal 2 oral

1

3

High-throughput

0.479

High

841607

STX4
Syntaxin-4

1

7

High-throughput

0.479

High

254866

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

11

High-throughput

0.445

High

388384

B3AT
Band 3 anion transport protein

1

5

High-throughput

0.445

High

480736

LEG1
Galectin-1

1

19

High-throughput

0.445

High

841610

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

12

High-throughput

0.445

High

841613

NIPA1
Magnesium transporter NIPA1

1

5

High-throughput

0.445

High

841616

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

3

High-throughput

0.445

High

841617

MOT10
Monocarboxylate transporter 10

1

8

High-throughput

0.445

High

841622

S13A1
Solute carrier family 13 member 1

1

1

High-throughput

0.445

High

138005

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.437

High

841615

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.437

High

841625

FBX6
F-box only protein 6

1

14

High-throughput

0.437

High

841627

DJC16
DnaJ homolog subfamily C member 16

1

4

High-throughput

0.437

High

170690

CLGN
Calmegin

1

7

High-throughput

0.407

High

841619

MF14A
Hippocampus abundant transcript 1 protein

1

6

High-throughput

0.407

High

841609

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

841629

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

841620

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

841623

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

841628

S45A1
Proton-associated sugar transporter A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025