HitPredict

Interactor 1: H2A1B (P04908)
Histone H2A type 1-B/E (Histone H2A.2) (Histone H2A/a) (Histone H2A/m)
Gene: H2AC4

Interactor 2: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.928

Property	Details
Experiments	26468281, 27832544, 29386386, 33589814, 34316702
Identification Methods	affinity chromatography technology, enzymatic study, x-ray crystallography, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 130 Hs			1 326
+	Hs
		470285 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		717932 H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		717876 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		555322 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		470533 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		391879 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		1151374 H2A2A_HUMAN (1-130): 2.9e-68: 203: 96.92		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1185208 H2A3_HUMAN (1-130): 3.34e-68: 203: 99.23		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		470514 H2A1_HUMAN (1-130): 3.61e-68: 203: 98.46		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		391856 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1216249 H2A2B_HUMAN (1-130): 8.97e-67: 199: 93.85		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1087089 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		555611 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Mm
		1145461 H2A2C_MOUSE (1-130): 1.54e-65: 196: 95.39		CHFR_MOUSE (6-167): 1.07e-33: 132: 19.39
+	Hs
		391666 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Hs
		555425 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Hs
		282470 H2A1B_HUMAN (1-130): 4.35e-68: 202: 100.00		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Hs
		282668 H2A2C_HUMAN (1-130): 1.54e-65: 196: 95.39		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Hs
		282515 H2AX_HUMAN (1-130): 3.67e-64: 193: 88.06		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Mm
		1145463 H2A2C_MOUSE (1-130): 1.54e-65: 196: 95.39		RNF8_MOUSE (2-102): 4.69e-20: 92.2: 26.73