Protein: SPB5
Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5)

Gene: SPB5, SERPINB5
Organism: Homo sapiens
Interactions: 162
UniProt ID: P36952

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0002009 - morphogenesis of an epithelium
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787729

TEST
Testisin

1

17

Small-scale

0.756

High

787686

IL31R
Interleukin-31 receptor subunit alpha

2

1

High-throughput

0.726

High

787618

MK09
Mitogen-activated protein kinase 9

3

4

High-throughput

0.667

High

787645

PLSI
Plastin-1

3

4

High-throughput

0.667

High

787699

VRK1
Serine/threonine-protein kinase VRK1

3

2

High-throughput

0.667

High

787707

EIF2A
Eukaryotic translation initiation factor 2A

3

5

High-throughput

0.667

High

787634

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

3

0

High-throughput

0.638

High

787708

NAA50
N-alpha-acetyltransferase 50

3

0

High-throughput

0.638

High

787649

STK11
Serine/threonine-protein kinase STK11

2

4

High-throughput

0.633

High

787617

GDF5
Growth/differentiation factor 5

2

8

High-throughput

0.628

High

787670

KHDC4
KH homology domain-containing protein 4

2

3

High-throughput

0.628

High

787694

CDK15
Cyclin-dependent kinase 15

2

8

High-throughput

0.628

High

787640

HDAC1
Histone deacetylase 1

2

1

Small-scale

0.625

High

787655

FNDC1
Fibronectin type III domain-containing protein 1

1

1

High-throughput

0.618

High

456201

CATD
Cathepsin D

1

1

High-throughput

0.618

High

713337

SPB3
Serpin B3

1

8

High-throughput

0.618

High

787660

MYOME
Myomegalin

2

5

High-throughput

0.611

High

787669

HDGR2
Hepatoma-derived growth factor-related protein 2

2

2

High-throughput

0.611

High

787723

DD19B
ATP-dependent RNA helicase DDX19B

2

9

High-throughput

0.611

High

423883

ALDH2
Aldehyde dehydrogenase, mitochondrial

3

1

High-throughput

0.609

High

787644

GPR18
N-arachidonyl glycine receptor

3

12

High-throughput

0.609

High

787647

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

7

High-throughput

0.609

High

787704

RBM24
RNA-binding protein 24

3

3

High-throughput

0.609

High

787727

KIF3A
Kinesin-like protein KIF3A

2

0

High-throughput

0.602

High

787652

SYT16
Synaptotagmin-16

2

1

High-throughput

0.574

High

787679

CCYL1
Cyclin-Y-like protein 1

2

2

High-throughput

0.574

High

787680

FRMD1
FERM domain-containing protein 1

2

3

High-throughput

0.574

High

787710

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

3

High-throughput

0.574

High

787715

TB22B
TBC1 domain family member 22B

2

7

High-throughput

0.574

High

787726

FCF1
rRNA-processing protein FCF1 homolog

2

3

High-throughput

0.574

High

787626

RHOA
Transforming protein RhoA

2

3

High-throughput

0.558

High

787650

RB11B
Ras-related protein Rab-11B

2

4

High-throughput

0.558

High

787656

SGO2
Shugoshin 2

2

1

High-throughput

0.558

High

787668

DDX46
Probable ATP-dependent RNA helicase DDX46

2

2

High-throughput

0.558

High

787690

FBX32
F-box only protein 32

1

1

Small-scale

0.552

High

636825

GSTM3
Glutathione S-transferase Mu 3

1

0

Small-scale

0.549

High

787671

ZC3C1
Zinc finger C3HC-type protein 1

2

4

High-throughput

0.549

High

219928

XRCC3
DNA repair protein XRCC3

1

1

High-throughput

0.541

High

294834

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

11

High-throughput

0.541

High

375247

RASK
GTPase KRas

1

7

High-throughput

0.541

High

395610

ESR1
Estrogen receptor

1

12

High-throughput

0.541

High

728071

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

High-throughput

0.541

High

787639

SMAD4
Mothers against decapentaplegic homolog 4

1

4

High-throughput

0.541

High

787646

CASP8
Caspase-8

1

8

High-throughput

0.541

High

362889

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.536

High

391577

FRIH
Ferritin heavy chain

1

4

High-throughput

0.536

High

602752

AATC
Aspartate aminotransferase, cytoplasmic

1

8

High-throughput

0.536

High

787622

MMP14
Matrix metalloproteinase-14

1

3

High-throughput

0.536

High

787637

HSF2
Heat shock factor protein 2

1

1

High-throughput

0.536

High

787651

ZYX
Zyxin

1

2

High-throughput

0.536

High

787662

JADE1
Protein Jade-1

1

1

High-throughput

0.536

High

787675

TEX14
Inactive serine/threonine-protein kinase TEX14

1

14

High-throughput

0.536

High

787689

TANK
TRAF family member-associated NF-kappa-B activator

1

1

High-throughput

0.536

High

787691

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

4

High-throughput

0.536

High

787697

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.536

High

787700

TREX2
Three prime repair exonuclease 2

1

2

High-throughput

0.536

High

787705

SRRT
Serrate RNA effector molecule homolog

1

5

High-throughput

0.536

High

787716

KLH11
Kelch-like protein 11

1

6

High-throughput

0.536

High

787722

HDAC9
Histone deacetylase 9

1

4

High-throughput

0.536

High

787724

SSUH2
Protein SSUH2 homolog

1

8

High-throughput

0.536

High

465945

CO1A2
Collagen alpha-2(I) chain

1

2

Small-scale

0.527

High

425351

ISG15
Ubiquitin-like protein ISG15

1

1

High-throughput

0.515

High

249577

SNX3
Sorting nexin-3

1

0

High-throughput

0.513

High

787701

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.513

High

787720

FBX3
F-box only protein 3

1

0

High-throughput

0.513

High

787728

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

3

Small-scale

0.501

High

787681

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.493

High

254855

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.489

High

325296

OR2A4
Olfactory receptor 2A4

1

13

High-throughput

0.489

High

787621

PTSS1
Phosphatidylserine synthase 1

1

2

High-throughput

0.489

High

787624

STX17
Syntaxin-17

1

9

High-throughput

0.489

High

787625

DSCR6
Protein ripply3

1

7

High-throughput

0.489

High

787632

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

9

High-throughput

0.489

High

787635

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

3

High-throughput

0.489

High

787657

LRC10
Leucine-rich repeat-containing protein 10

1

3

High-throughput

0.489

High

787685

O13C3
Olfactory receptor 13C3

1

4

High-throughput

0.489

High

787692

RM38
Large ribosomal subunit protein mL38

1

3

High-throughput

0.489

High

787693

F227B
Protein FAM227B

1

3

High-throughput

0.489

High

787711

COE2
Transcription factor COE2

1

5

High-throughput

0.489

High

461222

HS90A
Heat shock protein HSP 90-alpha

1

6

Small-scale

0.481

High

468137

HS90B
Heat shock protein HSP 90-beta

1

6

Small-scale

0.481

High

534723

BIP
Endoplasmic reticulum chaperone BiP

1

11

Small-scale

0.481

High

719409

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

1

4

Small-scale

0.481

High

787628

EF1A1
Elongation factor 1-alpha 1

1

3

Small-scale

0.481

High

787638

GOGA4
Golgin subfamily A member 4

1

3

Small-scale

0.481

High

167185

IRF6
Interferon regulatory factor 6

1

1

Small-scale

0.479

High

403877

GCR
Glucocorticoid receptor

1

12

High-throughput

0.479

High

457843

INVO
Involucrin

1

1

High-throughput

0.479

High

536635

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

623155

RO52
E3 ubiquitin-protein ligase TRIM21

1

7

Small-scale

0.479

High

729518

CASPE
Caspase-14

1

8

High-throughput

0.479

High

730423

1433S
14-3-3 protein sigma

1

5

High-throughput

0.479

High

787619

LEG7
Galectin-7

1

7

High-throughput

0.479

High

787620

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.479

High

787633

VIGLN
Vigilin

1

4

High-throughput

0.479

High

787641

PKP1
Plakophilin-1

1

7

High-throughput

0.479

High

787642

BLMH
Bleomycin hydrolase

1

2

High-throughput

0.479

High

787714

FBX6
F-box only protein 6

1

6

High-throughput

0.479

High

787718

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

787719

CALL5
Calmodulin-like protein 5

1

2

High-throughput

0.479

High

787616

MDHC
Malate dehydrogenase, cytoplasmic

1

0

Small-scale

0.460

High

787629

GSTO1
Glutathione S-transferase omega-1

1

0

Small-scale

0.460

High

787630

MT1H
Metallothionein-1H

1

0

Small-scale

0.460

High

787631

BASP1
Brain acid soluble protein 1

1

0

Small-scale

0.460

High

787654

LRRF1
Leucine-rich repeat flightless-interacting protein 1

1

0

Small-scale

0.460

High

48341

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

0

High-throughput

0.458

High

227064

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

627605

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.458

High

787627

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.458

High

787709

RANB3
Ran-binding protein 3

1

0

High-throughput

0.458

High

554175

BMP4
Bone morphogenetic protein 4

1

8

High-throughput

0.445

High

787665

OLFM4
Olfactomedin-4

1

3

High-throughput

0.445

High

787696

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.445

High

787698

PKP2
Plakophilin-2

1

7

High-throughput

0.445

High

687341

PTBP1
Polypyrimidine tract-binding protein 1

1

1

High-throughput

0.439

High

259545

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.437

High

787664

ANR12
Ankyrin repeat domain-containing protein 12

1

7

High-throughput

0.437

High

787676

CUL9
Cullin-9

1

4

High-throughput

0.437

High

787682

NKAI3
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3

1

1

High-throughput

0.437

High

787688

POF1B
Protein POF1B

1

1

High-throughput

0.437

High

787706

FACD2
Fanconi anemia group D2 protein

1

13

High-throughput

0.437

High

787712

UD110
UDP-glucuronosyltransferase 1A10

1

3

High-throughput

0.437

High

787713

RAB9B
Ras-related protein Rab-9B

1

6

High-throughput

0.437

High

47442

A0A6Q8PFP9
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein

1

1

High-throughput

0.407

High

66063

RP1BL
Ras-related protein Rap-1b-like protein

1

7

High-throughput

0.407

High

219607

B2L11
Bcl-2-like protein 11

1

2

High-throughput

0.407

High

261110

NSMA
Sphingomyelin phosphodiesterase 2

1

7

High-throughput

0.407

High

787623

GPC3
Glypican-3

1

3

High-throughput

0.407

High

787653

INF2
Inverted formin-2

1

3

High-throughput

0.407

High

787661

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.407

High

787666

DEFI8
Differentially expressed in FDCP 8 homolog

1

6

High-throughput

0.407

High

787667

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

2

High-throughput

0.407

High

787677

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.407

High

787684

IN80E
INO80 complex subunit E

1

1

High-throughput

0.407

High

787695

VPS35
Vacuolar protein sorting-associated protein 35

1

1

High-throughput

0.407

High

787703

RSRP1
Arginine/serine-rich protein 1

1

4

High-throughput

0.407

High

787717

CLDN1
Claudin domain-containing protein 1

1

2

High-throughput

0.407

High

787725

AP3M1
AP-3 complex subunit mu-1

1

1

High-throughput

0.407

High

787674

LACC1
Purine nucleoside phosphorylase LACC1

4

0

Small-scale

0.360

High

787672

GPBP1
Vasculin

2

0

High-throughput

0.328

High

787678

CCD82
Coiled-coil domain-containing protein 82

2

0

High-throughput

0.328

High

787687

CPLX3
Complexin-3

2

0

High-throughput

0.328

High

787721

FBXL4
F-box/LRR-repeat protein 4

2

0

High-throughput

0.328

High

272891

ZC11A
Zinc finger CCCH domain-containing protein 11A

2

0

High-throughput

0.318

High

329707

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

2

0

High-throughput

0.318

High

787643

PEBB
Core-binding factor subunit beta

2

0

High-throughput

0.318

High

284655

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

1

0

Small-scale

0.288

High

787673

PALB2
Partner and localizer of BRCA2

1

0

High-throughput

0.282

High

787658

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

628721

TBP
TATA-box-binding protein

1

0

Small-scale

0.251

Low

712145

TKT
Transketolase

1

0

Small-scale

0.251

Low

728925

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

Small-scale

0.251

Low

331969

KAT7
Histone acetyltransferase KAT7

1

0

High-throughput

0.249

Low

787636

UPAR
Urokinase plasminogen activator surface receptor

1

0

Small-scale

0.249

Low

787648

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.249

Low

787663

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.249

Low

787683

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

252750

AP180
Clathrin coat assembly protein AP180

1

0

High-throughput

0.232

Low

528426

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.232

Low

733689

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

1

0

High-throughput

0.232

Low

787659

TMM31
Transmembrane protein 31

1

0

High-throughput

0.232

Low

787702

SYT11
Synaptotagmin-11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025