HitPredict

Interactor 1: H2A2 (P04912)
Histone H2A.2
Gene: HTA2

Interactor 2: STH1 (P32597)
Nuclear protein STH1/NPS1 (EC 3.6.4.12) (ATP-dependent helicase STH1) (Chromatin structure-remodeling complex protein STH1) (SNF2 homolog)
Gene: STH1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	19106085, 37968396, 20190278, 21179020
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 132 Sc			1 1359
+	Sc
		392293 H2A2_YEAST (1-132): 1.1e-62: 189: 100.00		SNF2_YEAST (19-1357): 0: 733: 42.05
+	Sc
		392052 H2A1_YEAST (1-132): 2.35e-62: 188: 98.49		SNF2_YEAST (19-1357): 0: 733: 42.05
+	Hs
		391728 H2A1B_HUMAN (3-128): 1.35e-62: 189: 74.60		CHD9_HUMAN (80-1211): 0: 691: 23.01
+	Sc
		392595 H2A2_YEAST (1-132): 1.1e-62: 189: 100.00		ISW2_YEAST (334-991): 0: 684: 39.40
+	Hs
		391915 H2A1B_HUMAN (3-128): 1.35e-62: 189: 74.60		CHD8_HUMAN (78-1202): 0: 683: 22.67
+	Hs
		229433 H2A2B_HUMAN (3-127): 3.9e-63: 190: 74.40		SMCA5_HUMAN (366-1266): 0: 634: 30.99
+	Hs
		229279 H2A1B_HUMAN (3-128): 1.35e-62: 189: 74.60		SMCA5_HUMAN (366-1266): 0: 634: 30.99
+	Hs
		1018640 H2A1H_HUMAN (3-128): 3.42e-63: 190: 75.40		CHD3_HUMAN (295-1281): 0: 630: 25.58
+	Hs
		470278 H2A1_HUMAN (3-128): 1.07e-62: 189: 75.40		SMCA1_HUMAN (377-1266): 0: 631: 31.07
+	Hs
		391675 H2A1B_HUMAN (3-128): 1.35e-62: 189: 74.60		CHD3_HUMAN (295-1281): 0: 630: 25.58
+	Hs
		1059717 H2A2B_HUMAN (3-127): 3.9e-63: 190: 74.40		CHD4_HUMAN (295-1253): 0: 614: 25.95
+	Hs
		1059795 H2A1H_HUMAN (3-128): 3.42e-63: 190: 75.40		CHD4_HUMAN (295-1253): 0: 614: 25.95
+	Hs
		1059647 H2A2C_HUMAN (3-130): 9.18e-63: 189: 73.44		CHD4_HUMAN (295-1253): 0: 614: 25.95
+	Hs
		391704 H2A1B_HUMAN (3-128): 1.35e-62: 189: 74.60		CHD4_HUMAN (295-1253): 0: 614: 25.95
+	Hs
		470387 H2A1_HUMAN (3-128): 1.07e-62: 189: 75.40		CHD4_HUMAN (295-1253): 0: 614: 25.95
+	Sc
		392403 H2A2_YEAST (1-132): 1.1e-62: 189: 100.00		ISW1_YEAST (439-958): 1.81e-120: 405: 46.07
+	Sc
		392360 H2A2_YEAST (1-132): 1.1e-62: 189: 100.00		CHD1_YEAST (456-990): 1.42e-114: 395: 41.79
+	Sc
		392087 H2A1_YEAST (1-132): 2.35e-62: 188: 98.49		CHD1_YEAST (456-990): 1.42e-114: 395: 41.79
+	Sp
		144532 H2A1_SCHPO (1-132): 1.81e-63: 191: 81.82		HRP3_SCHPO (457-990): 6.18e-111: 383: 41.62
+	Hs
		151474 H2A1B_HUMAN (3-128): 1.35e-62: 189: 74.60		CHD2_HUMAN (458-1009): 2.19e-109: 383: 42.10