HitPredict

Interactor 1: ITB2 (P05107)
Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
Gene: ITGB2

Interactor 2: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11700305
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005178 - integrin binding GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 769 Hs			1 672
+	Hs
		403771 ITB1_HUMAN (5-766): 0: 703: 44.61		KPCA_HUMAN (1-672): 0: 794: 100.00
+	Hs
		396604 ITB2_HUMAN (1-769): 0: 742: 100.00		KPCB_HUMAN (1-664): 0: 749: 78.89
+	Hs
		396602 ITB2_HUMAN (1-769): 0: 742: 100.00		KPCG_HUMAN (1-670): 0: 706: 68.94
+	Mm
		222499 ITB3_MOUSE (21-766): 0: 642: 38.65		KPCA_MOUSE (1-672): 0: 784: 98.21
+	Mm
		222513 ITB3_MOUSE (21-766): 0: 642: 38.65		KPCB_MOUSE (1-664): 0: 747: 79.34
+	Hs
		396624 ITB2_HUMAN (1-769): 0: 742: 100.00		KPCE_HUMAN (8-664): 0: 635: 44.61
+	Hs
		396547 ITB3_HUMAN (22-766): 0: 613: 38.31		KPCB_HUMAN (1-664): 0: 749: 78.89
+	Hs
		403799 ITB1_HUMAN (5-766): 0: 703: 44.61		AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36
+	Hs
		396571 ITB3_HUMAN (22-766): 0: 613: 38.31		AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36
+	Hs
		396626 ITB2_HUMAN (1-769): 0: 742: 100.00		KPCD_HUMAN (9-167): 3.67e-57: 207: 39.65
+	Dm
		246711 TENM_DROME (613-720): 2.96e-11: 69.7: 13.49		KPC1_DROME (6-667): 0: 717: 66.07
+	Dm
		246850 TENM_DROME (613-720): 2.96e-11: 69.7: 13.49		AKT1_DROME (327-658): 1.05e-150: 451: 48.36
+	Dm
		247257 TENM_DROME (613-720): 2.96e-11: 69.7: 13.49		Q9VYN1_DROME (327-662): 3.33e-106: 356: 55.29