HitPredict

Interactor 1: S10A8 (P05109)
Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A)
Gene: S100A8

Interactor 2: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29117863
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0045087 - innate immune response GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 93 Hs			1 630
+	Hs
		416426 S10A9_HUMAN (2-88): 5.5e-28: 99.1: 26.09		TRI25_HUMAN (1-630): 3.52e-149: 447: 100.00
+	Hs
		1170676 HORN_HUMAN (2-89): 7.34e-30: 112: 25.00		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		685172 S10AB_HUMAN (2-93): 1.23e-31: 108: 26.04		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		396753 S10A8_HUMAN (1-93): 2.17e-30: 104: 100.00		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		661313 S10A2_HUMAN (1-92): 1.72e-29: 102: 26.04		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		1125321 FILA2_HUMAN (2-89): 4.61e-25: 99.1: 29.35		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		416459 S10A9_HUMAN (2-88): 5.5e-28: 99.1: 26.09		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		893806 S10AA_HUMAN (1-93): 5.15e-28: 98.7: 25.77		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		416649 S10A6_HUMAN (1-88): 9.59e-27: 95.3: 24.44		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		1171207 S10AG_HUMAN (3-92): 2.69e-23: 87.2: 25.26		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		1206192 HORN_HUMAN (2-89): 7.34e-30: 112: 25.00		TRIM6_HUMAN (3-332): 6.76e-31: 128: 13.39
+	Hs
		661388 S10A2_HUMAN (1-92): 1.72e-29: 102: 26.04		TRI11_HUMAN (6-288): 2.34e-31: 129: 19.08
+	Hs
		416677 S10A6_HUMAN (1-88): 9.59e-27: 95.3: 24.44		TRI11_HUMAN (6-288): 2.34e-31: 129: 19.08