Interactor 1: IL6 (P05231)
Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
Gene: IL6
Interactor 2: IL6RA (P08887)
Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)]
Gene: IL6R
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 1.00 | 0.982 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 14557255, 12643274, 2788034, 8702737, 9028955, 7744001, 9694899, 14656210, 7744875, 8706672, 15895091, 28265003, 11238858 |
| Identification Methods | pull down, affinity chromatography technology, molecular sieving, biochemical, coimmunoprecipitation, solid phase assay, anti tag coimmunoprecipitation, chromatography technology, electron microscopy, nuclear magnetic resonance and 2 others
more... |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | IL6~IL6Ra-bind |
| Common GO terms | GO:0002384 - hepatic immune response GO:0002446 - neutrophil mediated immunity GO:0002548 - monocyte chemotaxis GO:0002690 - positive regulation of leukocyte chemotaxis GO:0005576 - extracellular region and 19 others more... |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Last updated: 15 Jul 2024
