Interactor 1: HMDH (P04035)
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)
Gene: HMGCR
Interactor 2: INSI2 (Q9Y5U4)
Insulin-induced gene 2 protein (INSIG-2)
Gene: INSIG2
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.38 | 1.00 | 0.618 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 24371122 |
| Identification Methods | affinity chromatography technology |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | INSIG~Sterol-sensing |
| Common GO terms | GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0006695 - cholesterol biosynthetic process |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
