HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: PPR29 (Q5R3F8)
Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62)
Gene: ELFN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	39499777
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 820
+	Hs
		411039 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		RTN4R_HUMAN (57-298): 9.01e-57: 203: 24.50
+	Hs
		317541 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		SLIT2_HUMAN (18-264): 1.43e-35: 148: 17.13
+	Hs
		411089 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		FLRT3_HUMAN (92-364): 3.71e-25: 113: 12.32
+	Hs
		322527 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		SLIK3_HUMAN (52-226): 4.76e-14: 78.6: 32.20
+	Hs
		410931 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		SLIK4_HUMAN (40-223): 6.18e-12: 71.6: 26.67
+	Hs
		410908 ERBB2_HUMAN (1-1255): 0: 1292: 100.00		LRIG3_HUMAN (57-231): 7.68e-11: 68.2: 24.75
+	Hs
		363511 EGFR_HUMAN (16-1253): 0: 1078: 48.80		LRRT4_HUMAN (7-538): 7.04e-70: 243: 15.71
+	Hs
		363825 EGFR_HUMAN (16-1253): 0: 1078: 48.80		RTN4R_HUMAN (57-298): 9.01e-57: 203: 24.50
+	Hs
		363945 EGFR_HUMAN (16-1253): 0: 1078: 48.80		FLRT3_HUMAN (92-364): 3.71e-25: 113: 12.32
+	Hs
		1145744 ERBB4_HUMAN (6-1232): 0: 1103: 45.86		LRIG3_HUMAN (57-231): 7.68e-11: 68.2: 24.75
+	Hs
		322525 EGFR_HUMAN (16-1253): 0: 1078: 48.80		SLIK3_HUMAN (52-226): 4.76e-14: 78.6: 32.20
+	Hs
		363534 EGFR_HUMAN (16-1253): 0: 1078: 48.80		SLIK4_HUMAN (40-223): 6.18e-12: 71.6: 26.67
+	Hs
		363447 EGFR_HUMAN (16-1253): 0: 1078: 48.80		LRIG3_HUMAN (57-231): 7.68e-11: 68.2: 24.75
+	Hs
		320853 EGFR_HUMAN (16-1253): 0: 1078: 48.80		LRIG2_HUMAN (59-227): 6.57e-09: 61.6: 30.81
+	At
		87605 Y1684_ARATH (345-998): 8.39e-137: 443: 17.64		RGI4_ARATH (4-401): 2.79e-44: 174: 11.97
+	At
		265091 Y1142_ARATH (429-1001): 1.66e-139: 446: 17.13		PSKR2_ARATH (51-347): 2.03e-40: 163: 15.27
+	At
		87602 Y1684_ARATH (345-998): 8.39e-137: 443: 17.64		GSO1_ARATH (2-193): 5.83e-34: 142: 18.81
+	At
		88610 PSKR2_ARATH (275-979): 1.03e-141: 458: 13.83		Y3475_ARATH (214-401): 4.05e-11: 69: 9.52
+	At
		1426734 PSKR2_ARATH (275-979): 1.03e-141: 458: 13.83		Q9SD64_ARATH (206-383): 3.47e-10: 66: 10.00
+	At
		88599 PSKR2_ARATH (275-979): 1.03e-141: 458: 13.83		C0LGP3_ARATH (206-383): 3.5e-10: 66: 10.00