Protein: LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2)

Gene: LRIG2
Organism: Homo sapiens
Interactions: 66
UniProt ID: O94898

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0006509 - membrane protein ectodomain proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

320888

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

2

20

High-throughput

0.811

High

320861

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

3

High-throughput

0.691

High

320894

RTN4R
Reticulon-4 receptor

1

20

High-throughput

0.691

High

320907

BTNL2
Butyrophilin-like protein 2

1

12

High-throughput

0.691

High

320872

PON2
Serum paraoxonase/arylesterase 2

3

2

High-throughput

0.667

High

320853

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.665

High

320857

PGFRB
Platelet-derived growth factor receptor beta

1

11

Small-scale

0.665

High

320902

TMPS4
Transmembrane protease serine 4

1

9

High-throughput

0.665

High

168355

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.656

High

154783

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

15

High-throughput

0.618

High

320854

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.618

High

320874

CL12B
C-type lectin domain family 12 member B

1

11

High-throughput

0.618

High

320878

LYZL1
Lysozyme-like protein 1

1

1

High-throughput

0.618

High

320856

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.618

High

320863

BASI
Basigin

1

15

High-throughput

0.618

High

320866

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.618

High

320873

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

7

High-throughput

0.618

High

320879

TM11B
Transmembrane protease serine 11B

1

10

High-throughput

0.618

High

320883

CLC4D
C-type lectin domain family 4 member D

1

8

High-throughput

0.618

High

320887

LRC59
Leucine-rich repeat-containing protein 59

1

19

High-throughput

0.618

High

320910

CLC4E
C-type lectin domain family 4 member E

1

13

High-throughput

0.618

High

320892

CNPY3
Protein canopy homolog 3

2

13

High-throughput

0.601

High

320908

FBX2
F-box only protein 2

2

9

High-throughput

0.601

High

320901

FBX6
F-box only protein 6

2

9

High-throughput

0.584

High

320886

SPSB4
SPRY domain-containing SOCS box protein 4

2

12

High-throughput

0.549

High

320891

SPSB2
SPRY domain-containing SOCS box protein 2

2

10

High-throughput

0.549

High

320860

PSPC
Surfactant protein C

1

2

High-throughput

0.536

High

320867

MFAP4
Microfibril-associated glycoprotein 4

1

2

High-throughput

0.536

High

320870

IL5RA
Interleukin-5 receptor subunit alpha

1

8

High-throughput

0.536

High

320877

BRID5
BRICHOS domain-containing protein 5

1

2

High-throughput

0.536

High

320884

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.536

High

320885

T106A
Transmembrane protein 106A

1

2

High-throughput

0.536

High

320906

DNJB9
DnaJ homolog subfamily B member 9

1

2

High-throughput

0.536

High

320851

ECEL1
Endothelin-converting enzyme-like 1

1

0

High-throughput

0.513

High

320858

CFC1
Cryptic protein

1

0

High-throughput

0.513

High

320859

LYAG
Lysosomal alpha-glucosidase

1

0

High-throughput

0.513

High

320862

CALX
Calnexin

1

10

High-throughput

0.489

High

320865

DNSL1
Deoxyribonuclease-1-like 1

1

1

High-throughput

0.489

High

320875

WDR25
WD repeat-containing protein 25

1

2

High-throughput

0.489

High

320899

SDF2L
Stromal cell-derived factor 2-like protein 1

1

2

High-throughput

0.489

High

320904

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

1

High-throughput

0.489

High

217639

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

320852

EYA4
Protein phosphatase EYA4

1

2

High-throughput

0.479

High

320864

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.479

High

320868

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.479

High

320871

STX4
Syntaxin-4

1

7

High-throughput

0.479

High

320881

DHB11
Estradiol 17-beta-dehydrogenase 11

1

5

High-throughput

0.479

High

320889

DNJC1
DnaJ homolog subfamily C member 1

1

6

High-throughput

0.479

High

320903

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.479

High

320909

WWC3
Protein WWC3

1

5

High-throughput

0.479

High

320876

S27A4
Long-chain fatty acid transport protein 4

1

7

High-throughput

0.445

High

320911

S27A6
Long-chain fatty acid transport protein 6

1

7

High-throughput

0.445

High

173805

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

12

High-throughput

0.437

High

320855

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.437

High

320869

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.437

High

320893

DERL1
Derlin-1

1

1

High-throughput

0.437

High

320896

DJC25
DnaJ homolog subfamily C member 25

1

5

High-throughput

0.437

High

320897

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.437

High

320898

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.437

High

320900

ST7
Suppressor of tumorigenicity 7 protein

1

3

High-throughput

0.437

High

320905

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.437

High

170591

CLGN
Calmegin

1

10

High-throughput

0.407

High

320880

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

320882

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.279

Low

320890

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

320895

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025