HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	9564850, 26043024
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005770 - late endosome GO:0044877 - protein-containing complex binding GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1382 Hs			1 440
+	Hs
		1036611 NTRK2_HUMAN (996-1292): 3.55e-70: 254: 43.38		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		384793 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1036607 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Rn
		139616 NTRK1_RAT (996-1286): 4.48e-67: 245: 41.95		SQSTM_RAT (1-440): 0: 746: 90.95
+	Hs
		609276 FGFR3_HUMAN (1015-1287): 2.21e-62: 231: 40.78		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Mm
		546304 NTRK2_MOUSE (996-1292): 3.84e-69: 251: 43.05		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Mm
		1112477 NTRK1_MOUSE (996-1286): 9.52e-68: 247: 42.28		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Hs
		665280 EPHA2_HUMAN (674-1320): 4.56e-172: 540: 21.91		MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19
+	Hs
		319848 EPHA7_HUMAN (562-1356): 4.76e-172: 541: 19.48		HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50
+	Hs
		385120 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19