HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21834013
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 551
+	Mm
		411919 LCK_MOUSE (1-509): 0: 657: 96.86		CSF3R_MOUSE (7-361): 5.25e-39: 154: 14.80
+	Hs
		522759 SRC_HUMAN (20-507): 0: 586: 55.00		EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49
+	Hs
		433567 LYN_HUMAN (1-509): 0: 582: 62.72		EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49
+	Mm
		540265 LYN_MOUSE (1-509): 0: 585: 62.33		EPOR_MOUSE (7-427): 1.75e-58: 204: 19.30
+	Hs
		522803 SRC_HUMAN (20-507): 0: 586: 55.00		EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15
+	Mm
		403425 SRC_MOUSE (28-507): 0: 583: 57.05		EPHB2_MOUSE (28-329): 4.33e-52: 193: 14.47
+	Hs
		433265 YES_HUMAN (26-507): 0: 581: 58.06		EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15
+	Hs
		442875 HCK_HUMAN (1-509): 0: 602: 65.04		CSF3R_HUMAN (5-360): 1.61e-44: 170: 14.48
+	Hs
		411991 FYN_HUMAN (30-507): 0: 586: 59.01		IL7RA_HUMAN (92-351): 4.68e-52: 185: 16.60
+	Hs
		433961 LYN_HUMAN (1-509): 0: 582: 62.72		CSF3R_HUMAN (5-360): 1.61e-44: 170: 14.48
+	Hs
		412028 FYN_HUMAN (30-507): 0: 586: 59.01		IL3RA_HUMAN (10-311): 9.99e-45: 164: 15.36
+	Mm
		435879 HCK_MOUSE (1-509): 0: 590: 63.99		CSF3R_MOUSE (7-361): 5.25e-39: 154: 14.80
+	Hs
		433772 LYN_HUMAN (1-509): 0: 582: 62.72		EPHA7_HUMAN (27-329): 4.27e-39: 155: 14.83
+	Hs
		337360 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15
+	Hs
		665558 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15
+	Mm
		872619 ABL2_MOUSE (57-502): 6.98e-164: 496: 42.73		EPHB2_MOUSE (28-329): 4.33e-52: 193: 14.47
+	Hs
		442787 HCK_HUMAN (1-509): 0: 602: 65.04		IL6RB_HUMAN (27-351): 1.04e-13: 76.1: 13.11
+	Hs
		412051 FYN_HUMAN (30-507): 0: 586: 59.01		IL3RB_HUMAN (13-240): 2.54e-16: 84.6: 17.01
+	Hs
		433612 LYN_HUMAN (1-509): 0: 582: 62.72		IL3RB_HUMAN (13-240): 2.54e-16: 84.6: 17.01
+	Hs
		789068 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		EPHA7_HUMAN (27-329): 4.27e-39: 155: 14.83