HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: GRB14 (Q14449)
Growth factor receptor-bound protein 14 (GRB14 adapter protein)
Gene: GRB14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	16934761, 11726652, 19648926, 24535599
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3, BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0008286 - insulin receptor signaling pathway GO:0010008 - endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 540
+	Rn
		292434 T2CB11_RAT (1-1382): 0: 1538: 94.87		GRB14_RAT (1-540): 0: 654: 85.00
+	Rn
		292431 INSR_RAT (1-1382): 0: 1527: 94.44		GRB14_RAT (1-540): 0: 654: 85.00
+	Hs
		411376 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB10_HUMAN (5-540): 0: 551: 54.94
+	Hs
		411384 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB7_HUMAN (63-540): 5.06e-175: 506: 50.21
+	Hs
		411288 INSR_HUMAN (1-1382): 0: 1530: 100.00		VAV_HUMAN (100-534): 8.93e-99: 319: 16.35
+	Hs
		411523 INSR_HUMAN (1-1382): 0: 1530: 100.00		VAV3_HUMAN (102-534): 1.45e-85: 284: 13.03
+	Hs
		411292 INSR_HUMAN (1-1382): 0: 1530: 100.00		PLCG1_HUMAN (238-540): 2.64e-43: 167: 17.67
+	Rn
		499158 INSR_RAT (1-1382): 0: 1527: 94.44		PLCG1_RAT (238-540): 8.25e-43: 166: 17.98
+	Hs
		411329 INSR_HUMAN (1-1382): 0: 1530: 100.00		CSK_HUMAN (398-533): 1.07e-30: 126: 28.26
+	Hs
		411352 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Rn
		783510 T2CB11_RAT (1-1382): 0: 1538: 94.87		PTN11_RAT (428-526): 1.57e-21: 100: 35.78
+	Hs
		411363 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTN11_HUMAN (428-526): 1.57e-21: 100: 35.78
+	Hs
		411306 INSR_HUMAN (1-1382): 0: 1530: 100.00		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Rn
		544879 INSR_RAT (1-1382): 0: 1527: 94.44		P85A_RAT (315-535): 8.19e-19: 92.2: 14.60
+	Hs
		411311 INSR_HUMAN (1-1382): 0: 1530: 100.00		PTN6_HUMAN (421-523): 1.14e-14: 78.7: 26.79
+	Mm
		546262 INSR_MOUSE (1-1382): 0: 1509: 94.36		P85A_MOUSE (315-535): 4.26e-19: 93: 14.60
+	Mm
		546274 INSR_MOUSE (1-1382): 0: 1509: 94.36		GRB10_MOUSE (5-88): 2.67e-15: 80.7: 28.57
+	Hs
		433523 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		LYN_HUMAN (351-539): 6.38e-42: 159: 18.59
+	Hs
		435546 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Hs
		435549 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PTN6_HUMAN (421-523): 1.14e-14: 78.7: 26.79