HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: DJC10 (Q8IXB1)
DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr)
Gene: DNAJC10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 793
+	Hs
		435692 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DJC10_HUMAN (1-793): 0: 609: 100.00
+	Hs
		537757 INSRR_HUMAN (13-1341): 0: 1293: 51.12		DJC10_HUMAN (1-793): 0: 609: 100.00
+	Hs
		411391 INSR_HUMAN (1-1382): 0: 1530: 100.00		PDIA6_HUMAN (135-451): 3.77e-40: 155: 16.62
+	Rn
		544870 INSR_RAT (1-1382): 0: 1527: 94.44		PDIA6_RAT (117-451): 1.19e-39: 154: 17.10
+	Hs
		411285 INSR_HUMAN (1-1382): 0: 1530: 100.00		PDIA4_HUMAN (153-643): 4.32e-35: 143: 13.67
+	Rn
		102493 INSR_RAT (1-1382): 0: 1527: 94.44		G3V6T7_RAT (132-643): 2.85e-35: 144: 13.69
+	Rn
		514117 INSR_RAT (1-1382): 0: 1527: 94.44		PDIA3_RAT (236-674): 2.15e-25: 112: 12.92
+	Hs
		411515 INSR_HUMAN (1-1382): 0: 1530: 100.00		DJB11_HUMAN (19-108): 1.04e-22: 102: 47.78
+	Hs
		411442 INSR_HUMAN (1-1382): 0: 1530: 100.00		TXND5_HUMAN (687-793): 2.4e-20: 96.6: 25.00
+	Hs
		411271 INSR_HUMAN (1-1382): 0: 1530: 100.00		PDIA1_HUMAN (86-231): 1.07e-10: 66.9: 18.00
+	Rn
		388065 INSR_RAT (1-1382): 0: 1527: 94.44		PDIA1_RAT (86-250): 2.49e-11: 68.9: 15.39
+	Hs
		435520 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PDIA4_HUMAN (153-643): 4.32e-35: 143: 13.67
+	Hs
		435790 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DJB11_HUMAN (19-108): 1.04e-22: 102: 47.78
+	Hs
		435789 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		DNJB9_HUMAN (19-128): 4.03e-16: 80.1: 40.00
+	Hs
		423108 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		PDIA1_HUMAN (86-231): 1.07e-10: 66.9: 18.00
+	Hs
		537779 INSRR_HUMAN (13-1341): 0: 1293: 51.12		DJB11_HUMAN (19-108): 1.04e-22: 102: 47.78
+	Hs
		537760 INSRR_HUMAN (13-1341): 0: 1293: 51.12		TXND5_HUMAN (687-793): 2.4e-20: 96.6: 25.00
+	Hs
		531732 EPHB2_HUMAN (521-1316): 3.12e-175: 551: 20.21		PDIA4_HUMAN (153-643): 4.32e-35: 143: 13.67
+	Hs
		531731 EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68		PDIA4_HUMAN (153-643): 4.32e-35: 143: 13.67
+	Hs
		665541 EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68		DJB11_HUMAN (19-108): 1.04e-22: 102: 47.78