HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 870
+	Hs
		442794 HCK_HUMAN (1-509): 0: 602: 65.04		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		412090 FYN_HUMAN (30-507): 0: 586: 59.01		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		522862 SRC_HUMAN (20-507): 0: 586: 55.00		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		433651 LYN_HUMAN (1-509): 0: 582: 62.72		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		522926 SRC_HUMAN (20-507): 0: 586: 55.00		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		412411 FYN_HUMAN (30-507): 0: 586: 59.01		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Hs
		337399 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		337437 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		337597 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Ce
		220206 SRC2_CAEEL (35-507): 0: 526: 47.71		DYN1_CAEEL (3-823): 0: 899: 61.86
+	Ce
		106652 SRC1_CAEEL (1-508): 8.64e-179: 514: 44.84		DYN1_CAEEL (3-823): 0: 899: 61.86