HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	10449731
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 875
+	Hs
		846460 BLK_HUMAN (1-509): 0: 557: 59.35		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		412081 FYN_HUMAN (30-507): 0: 586: 59.01		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		522850 SRC_HUMAN (20-507): 0: 586: 55.00		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		433282 YES_HUMAN (26-507): 0: 581: 58.06		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		411864 LCK_HUMAN (1-509): 0: 661: 100.00		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		412307 FYN_HUMAN (30-507): 0: 586: 59.01		ITCH_HUMAN (325-873): 0: 579: 24.78
+	Hs
		337392 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		789045 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		454848 FGR_HUMAN (1-507): 0: 579: 52.76		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		337535 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		NED4L_HUMAN (247-873): 0: 575: 22.52
+	Hs
		808270 SRMS_HUMAN (29-502): 3.04e-160: 465: 41.34		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		789085 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		NED4L_HUMAN (247-873): 0: 575: 22.52
+	Hs
		996573 ITK_HUMAN (7-500): 1.08e-177: 515: 33.33		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		1299632 SRMS_HUMAN (29-502): 3.04e-160: 465: 41.34		NED4L_HUMAN (247-873): 0: 575: 22.52
+	Hs
		986397 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04
+	Hs
		337496 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97