HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: MRCKB (Q9Y5S2)
Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)
Gene: CDC42BPB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Pkinase, C1_1~SH2
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006468 - protein phosphorylation GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 1711
+	Hs
		434101 LYN_HUMAN (1-509): 0: 582: 62.72		MRCKB_HUMAN (1-1711): 0: 1556: 100.00
+	Hs
		411758 LCK_HUMAN (1-509): 0: 661: 100.00		MRCKA_HUMAN (1-1710): 0: 1386: 60.78
+	Hs
		433818 LYN_HUMAN (1-509): 0: 582: 62.72		MRCKA_HUMAN (1-1710): 0: 1386: 60.78
+	Hs
		411727 LCK_HUMAN (1-509): 0: 661: 100.00		STK38_HUMAN (4-421): 5.25e-119: 385: 38.77
+	Hs
		296394 LYN_HUMAN (1-509): 0: 582: 62.72		STK10_HUMAN (43-1015): 1.26e-120: 406: 16.50
+	Hs
		433470 YES_HUMAN (26-507): 0: 581: 58.06		SIK2_HUMAN (60-810): 1.3e-120: 405: 16.86
+	Hs
		434089 LYN_HUMAN (1-509): 0: 582: 62.72		ST38L_HUMAN (1-421): 5.35e-120: 388: 37.93
+	Hs
		433510 YES_HUMAN (26-507): 0: 581: 58.06		ST38L_HUMAN (1-421): 5.35e-120: 388: 37.93
+	Hs
		411994 FYN_HUMAN (30-507): 0: 586: 59.01		KAPCA_HUMAN (48-375): 1.99e-119: 382: 34.72
+	Hs
		412014 FYN_HUMAN (30-507): 0: 586: 59.01		KAPCB_HUMAN (50-375): 2.2e-119: 382: 35.52
+	Hs
		434067 LYN_HUMAN (1-509): 0: 582: 62.72		TNIK_HUMAN (52-833): 5.89e-94: 336: 14.30
+	Hs
		412203 FYN_HUMAN (30-507): 0: 586: 59.01		KS6A2_HUMAN (2-389): 6.73e-94: 323: 21.41
+	Hs
		433360 YES_HUMAN (26-507): 0: 581: 58.06		KS6A2_HUMAN (2-389): 6.73e-94: 323: 21.41
+	Hs
		412205 FYN_HUMAN (30-507): 0: 586: 59.01		KS6A1_HUMAN (2-354): 1.8e-89: 310: 22.16
+	Hs
		523170 SRC_HUMAN (20-507): 0: 586: 55.00		LATS2_HUMAN (66-375): 4.05e-70: 259: 40.34
+	Hs
		789116 FRK_HUMAN (50-503): 0: 530: 48.20		KS6A1_HUMAN (2-354): 1.8e-89: 310: 22.16
+	Hs
		789133 FRK_HUMAN (50-503): 0: 530: 48.20		LATS2_HUMAN (66-375): 4.05e-70: 259: 40.34
+	Hs
		337568 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		LATS2_HUMAN (66-375): 4.05e-70: 259: 40.34
+	Hs
		433749 LYN_HUMAN (1-509): 0: 582: 62.72		ROCK1_HUMAN (360-1074): 6.44e-17: 89.6: 13.02