HitPredict

Interactor 1: HSPB1 (P04792)
Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Heat shock protein family B member 1) (Stress-responsive protein 27) (SRP27)
Gene: HSPB1

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)
Gene: SQSTM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 0.60 0.658

The method score is based on:

Property Details
Experiments 25277244, 30669930, 39098523
Identification Methods two hybrid, affinity chromatography technology, proximity labelling technology, reverse ras recruitment system
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005080 - protein kinase C binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0019901 - protein kinase binding
GO:0035556 - intracellular signal transduction
and 3 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 205
Hs

1 440
+ Hs
+ Dm
+ Dm
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025