HitPredict

Interactor 1: EVE (P06602)
Segmentation protein even-skipped
Gene: EVE

Interactor 2: UBX (P83949)
Homeotic protein ultrabithorax
Gene: UBX

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25869471, 30247122
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 376 Dm			1 389
+	Dm
		950110 Q9XZU0_DROME (62-368): 4.69e-40: 147: 19.51		UBX_DROME (1-389): 3.26e-124: 365: 100.00
+	Dm
		949988 AL_DROME (30-315): 1.25e-36: 138: 24.84		UBX_DROME (1-389): 3.26e-124: 365: 100.00
+	Dm
		447432 GSBN_DROME (13-347): 9.84e-32: 126: 15.52		UBX_DROME (1-389): 3.26e-124: 365: 100.00
+	Dm
		415577 EVE_DROME (1-376): 1.24e-43: 157: 100.00		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Dm
		415559 PRD_DROME (16-347): 3.39e-39: 149: 19.52		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Dm
		668320 Q9XZU0_DROME (62-368): 4.69e-40: 147: 19.51		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Dm
		668243 AL_DROME (30-315): 1.25e-36: 138: 24.84		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Hs
		538719 HXB2_HUMAN (25-271): 1.84e-35: 134: 24.50		HXB2_HUMAN (240-385): 2.91e-41: 150: 38.10
+	Dm
		185806 PAX6_DROME (29-363): 6.17e-31: 126: 20.54		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Dm
		447431 GSBN_DROME (13-347): 9.84e-32: 126: 15.52		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Dm
		367168 EVE_DROME (1-376): 1.24e-43: 157: 100.00		ANTP_DROME (161-375): 5.32e-31: 123: 32.56
+	Mm
		446930 HXD3_MOUSE (33-269): 2.73e-41: 152: 25.50		MEOX2_MOUSE (114-366): 8.16e-32: 123: 19.76
+	Hs
		678775 HXD3_HUMAN (14-269): 1.65e-39: 147: 22.96		HXC8_HUMAN (146-363): 3.56e-32: 123: 31.65
+	Dm
		415571 EVE_DROME (1-376): 1.24e-43: 157: 100.00		SCR_DROME (289-353): 5.65e-24: 104: 80.00
+	Hs
		453052 HXA7_HUMAN (44-145): 1.21e-34: 129: 32.11		HXB7_HUMAN (139-364): 7.88e-33: 124: 31.86
+	Mm
		223191 Q8VD35_MOUSE (35-260): 3.27e-33: 127: 20.88		TLX3_MOUSE (118-388): 1.11e-31: 123: 16.97
+	Dm
		185797 PAX6_DROME (29-363): 6.17e-31: 126: 20.54		ANTP_DROME (161-375): 5.32e-31: 123: 32.56
+	Dm
		367210 PRD_DROME (16-347): 3.39e-39: 149: 19.52		FTZ_DROME (296-353): 9.77e-22: 97.8: 79.31
+	Dm
		447327 HMPB_DROME (25-134): 7.31e-33: 131: 40.00		SCR_DROME (289-353): 5.65e-24: 104: 80.00
+	Ce
		106235 VAB3_CAEEL (5-311): 8.12e-35: 135: 17.15		PAL1_CAEEL (261-358): 4e-19: 88.2: 45.37