HitPredict

Interactor 1: BIP (P06761)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) (Steroidogenesis-activator polypeptide)
Gene: Hspa5

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016020 - membrane GO:0019904 - protein domain specific binding GO:0030335 - positive regulation of cell migration and 1 others more... GO:0043025 - neuronal cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Rn			1 1383
+	Rn
		544811 HSP7C_RAT (26-637): 0: 910: 65.85		INSR_RAT (1-1383): 0: 1575: 100.00
+	Hs
		411284 BIP_HUMAN (1-654): 0: 918: 98.47		INSR_HUMAN (27-1383): 0: 1527: 95.43
+	Hs
		435510 BIP_HUMAN (1-654): 0: 918: 98.47		IGF1R_HUMAN (13-1381): 0: 1302: 55.77
+	Hs
		435511 HSP7C_HUMAN (26-637): 0: 910: 65.85		IGF1R_HUMAN (13-1381): 0: 1302: 55.77
+	Hs
		501728 BIP_HUMAN (1-654): 0: 918: 98.47		EPHB2_HUMAN (662-1317): 0: 577: 23.01
+	Hs
		502130 BIP_HUMAN (1-654): 0: 918: 98.47		EPHA7_HUMAN (664-1321): 0: 568: 22.55
+	Hs
		501727 BIP_HUMAN (1-654): 0: 918: 98.47		EPHA8_HUMAN (663-1323): 1.14e-174: 548: 22.59
+	Hs
		445816 BIP_HUMAN (1-654): 0: 918: 98.47		ROS1_HUMAN (1020-1292): 1.06e-71: 267: 49.46
+	Hs
		502677 BIP_HUMAN (1-654): 0: 918: 98.47		ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57
+	Hs
		384161 BIP_HUMAN (1-654): 0: 918: 98.47		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		384372 HS71L_HUMAN (24-647): 0: 912: 63.16		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		384163 HSP7C_HUMAN (26-637): 0: 910: 65.85		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		502148 BIP_HUMAN (1-654): 0: 918: 98.47		NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80
+	Hs
		501675 BIP_HUMAN (1-654): 0: 918: 98.47		ERBB3_HUMAN (5-368): 5.74e-31: 135: 19.70
+	Hs
		337838 BIP_HUMAN (1-654): 0: 918: 98.47		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		338520 Q59EJ3_HUMAN (19-635): 0: 915: 63.55		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		503428 HSP7C_HUMAN (26-637): 0: 910: 65.85		ERBB3_HUMAN (5-368): 5.74e-31: 135: 19.70
+	Hs
		338019 HS71L_HUMAN (24-647): 0: 912: 63.16		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		337839 HSP7C_HUMAN (26-637): 0: 910: 65.85		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		383559 BIP_HUMAN (1-654): 0: 918: 98.47		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83