HitPredict

Interactor 1: BIP (P06761)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) (Steroidogenesis-activator polypeptide)
Gene: Hspa5

Interactor 2: ERP29 (P52555)
Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 31) (ERp31)
Gene: ERP29

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	22665516
Identification Methods	transcriptional complementation assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005788 - endoplasmic reticulum lumen GO:0005790 - smooth endoplasmic reticulum GO:0009986 - cell surface GO:0034976 - response to endoplasmic reticulum stress and 1 others more... GO:0042470 - melanosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 654 Rn			1 260
+	Hs
		501732 BIP_HUMAN (1-654): 0: 918: 98.47		ERP29_HUMAN (1-260): 2.45e-80: 244: 89.66
+	Mm
		588708 BIP_MOUSE (1-654): 0: 925: 99.69		ERP29_MOUSE (25-260): 9.73e-77: 235: 91.95
+	Hs
		501734 BIP_HUMAN (1-654): 0: 918: 98.47		PDIA3_HUMAN (28-150): 1.29e-33: 129: 13.49
+	Rn
		419262 BIP_RAT (1-654): 0: 926: 100.00		PDIA4_RAT (37-231): 2.43e-29: 117: 14.78
+	Hs
		423116 BIP_HUMAN (1-654): 0: 918: 98.47		PDIA1_HUMAN (34-150): 4.3e-32: 124: 15.00
+	Mm
		434692 BIP_MOUSE (1-654): 0: 925: 99.69		PDIA4_MOUSE (37-231): 1.58e-28: 115: 14.78
+	Hs
		503509 HSP7C_HUMAN (26-637): 0: 910: 65.85		PDIA3_HUMAN (28-150): 1.29e-33: 129: 13.49
+	Hs
		502121 BIP_HUMAN (1-654): 0: 918: 98.47		PDIA6_HUMAN (13-226): 1.8e-30: 119: 15.84
+	Hs
		423117 HSP7C_HUMAN (26-637): 0: 910: 65.85		PDIA1_HUMAN (34-150): 4.3e-32: 124: 15.00
+	Hs
		501620 BIP_HUMAN (1-654): 0: 918: 98.47		PDIA4_HUMAN (37-214): 2.04e-28: 115: 14.92
+	Hs
		503348 HSP7C_HUMAN (26-637): 0: 910: 65.85		PDIA4_HUMAN (37-214): 2.04e-28: 115: 14.92
+	Hs
		502329 BIP_HUMAN (1-654): 0: 918: 98.47		TXND5_HUMAN (57-227): 1.67e-22: 97.6: 14.84
+	Mm
		88470 BIP_MOUSE (1-654): 0: 925: 99.69		PDIA2_MOUSE (27-219): 1.28e-19: 89.4: 16.84
+	Hs
		504411 HSP7C_HUMAN (26-637): 0: 910: 65.85		TXND5_HUMAN (57-227): 1.67e-22: 97.6: 14.84
+	Nc
		945003 BIP_NEUCR (16-654): 0: 825: 68.13		ERP38_NEUCR (40-214): 1.01e-25: 105: 18.13
+	Nc
		945001 BIP_NEUCR (16-654): 0: 825: 68.13		Q7S399_NEUCR (38-212): 4.33e-14: 73.2: 19.77