Protein: ICMT
Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT)

Gene: ICMT
Organism: Homo sapiens
Interactions: 54
UniProt ID: O60725

Gene Ontology (top 5):
GO:0003880 - protein C-terminal carboxyl O-methyltransferase activity
GO:0004671 - protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006481 - C-terminal protein methylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

239263

TRI32
E3 ubiquitin-protein ligase TRIM32

2

0

High-throughput

0.580

High

239264

PDZ1I
PDZK1-interacting protein 1

2

0

High-throughput

0.580

High

239271

RN19B
E3 ubiquitin-protein ligase RNF19B

2

0

High-throughput

0.580

High

239276

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

239239

OXSR1
Serine/threonine-protein kinase OSR1

2

1

High-throughput

0.574

High

239265

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

239250

CALX
Calnexin

2

0

High-throughput

0.547

High

239278

AQP3
Aquaporin-3

1

1

High-throughput

0.536

High

171899

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.513

High

239244

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

High-throughput

0.513

High

239262

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

239274

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

239275

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

239279

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

239245

RAC2
Ras-related C3 botulinum toxin substrate 2

1

1

Small-scale

0.501

High

239259

RHOA
Transforming protein RhoA

1

1

Small-scale

0.501

High

239253

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.489

High

239256

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

1

High-throughput

0.489

High

48196

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.458

High

239241

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

239258

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

239266

CUL3
Cullin-3

1

0

High-throughput

0.458

High

239270

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.458

High

239282

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

239269

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

239284

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.426

High

119593

STXB3
Syntaxin-binding protein 3

2

0

High-throughput

0.328

High

239238

RA51D
DNA repair protein RAD51 homolog 4

2

0

High-throughput

0.328

High

239242

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

2

0

High-throughput

0.328

High

239252

GRAN
Grancalcin

2

0

High-throughput

0.328

High

239247

MUC1
Mucin-1

2

0

High-throughput

0.316

High

239257

KCNJ6
G protein-activated inward rectifier potassium channel 2

2

0

High-throughput

0.316

High

239268

AR13B
ADP-ribosylation factor-like protein 13B

2

0

High-throughput

0.316

High

239243

KPCB
Protein kinase C beta type

2

0

High-throughput

0.298

High

239248

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.298

High

156758

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

239273

RELL1
RELT-like protein 1

1

0

High-throughput

0.279

Low

239277

PPM1E
Protein phosphatase 1E

1

0

High-throughput

0.279

Low

239287

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

239240

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

239246

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

239249

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

239251

DUS1
Dual specificity protein phosphatase 1

1

0

High-throughput

0.249

Low

239254

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

239255

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

239260

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

239261

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

239267

KS6A1
Ribosomal protein S6 kinase alpha-1

1

0

High-throughput

0.249

Low

239272

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.249

Low

239280

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

239281

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

239283

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

239285

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.249

Low

239286

UBQL2
Ubiquilin-2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024