Protein: CDC16
Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6)

Gene: CDC16
Organism: Homo sapiens
Interactions: 219
UniProt ID: Q13042

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

718554

CDC27
Cell division cycle protein 27 homolog

25

17

Small-scale

0.990

High

1093010

CDC26
Anaphase-promoting complex subunit CDC26

14

6

Small-scale

0.987

High

1093082

ANC2
Anaphase-promoting complex subunit 2

8

20

Small-scale

0.968

High

1093078

CDC23
Cell division cycle protein 23 homolog

7

19

High-throughput

0.967

High

1093079

APC7
Anaphase-promoting complex subunit 7

6

19

High-throughput

0.950

High

1093028

APC16
Anaphase-promoting complex subunit 16

6

5

High-throughput

0.949

High

948522

APC15
Anaphase-promoting complex subunit 15

3

6

Small-scale

0.861

High

1093012

TTC8
Tetratricopeptide repeat protein 8

2

20

High-throughput

0.811

High

1093081

APC4
Anaphase-promoting complex subunit 4

15

11

Small-scale

0.762

High

1086841

CDC20
Cell division cycle protein 20 homolog

14

20

Small-scale

0.759

High

1093086

FZR1
Fizzy-related protein homolog

8

20

Small-scale

0.750

High

251748

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

7

18

Small-scale

0.744

High

1093044

APC1
Anaphase-promoting complex subunit 1

6

11

Small-scale

0.737

High

1093080

APC5
Anaphase-promoting complex subunit 5

6

12

High-throughput

0.734

High

1093084

FBX5
F-box only protein 5

5

7

Small-scale

0.723

High

908820

NEK2
Serine/threonine-protein kinase Nek2

5

12

Small-scale

0.712

High

1093038

APC13
Anaphase-promoting complex subunit 13

4

5

High-throughput

0.697

High

1093089

TRI33
E3 ubiquitin-protein ligase TRIM33

4

12

Small-scale

0.694

High

48139

IFT56
Intraflagellar transport protein 56

1

1

High-throughput

0.691

High

1093087

APC10
Anaphase-promoting complex subunit 10

4

17

Small-scale

0.691

High

315530

RECQ4
ATP-dependent DNA helicase Q4

3

9

High-throughput

0.667

High

351274

TTLL1
Polyglutamylase complex subunit TTLL1

3

2

High-throughput

0.667

High

1092957

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

3

8

Small-scale

0.650

High

1092962

MDC1
Mediator of DNA damage checkpoint protein 1

3

18

Small-scale

0.640

High

74024

MYO9A
Unconventional myosin-IXa

2

1

High-throughput

0.628

High

135923

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

2

2

High-throughput

0.628

High

180801

TIF1A
Transcription intermediary factor 1-alpha

2

20

High-throughput

0.628

High

224112

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

2

17

High-throughput

0.628

High

278327

NCOR1
Nuclear receptor corepressor 1

2

11

High-throughput

0.628

High

323352

TRI37
E3 ubiquitin-protein ligase TRIM37

2

14

High-throughput

0.628

High

896374

ERF
ETS domain-containing transcription factor ERF

2

1

High-throughput

0.628

High

1092970

TBB8
Tubulin beta-8 chain

2

8

High-throughput

0.628

High

1092971

ANO6
Anoctamin-6

2

3

High-throughput

0.628

High

1092975

CE350
Centrosome-associated protein 350

2

3

High-throughput

0.628

High

1092983

BCOR
BCL-6 corepressor

2

7

High-throughput

0.628

High

1092984

CO039
Uncharacterized protein C15orf39

2

7

High-throughput

0.628

High

1092985

FA83H
Protein FAM83H

2

1

High-throughput

0.628

High

1092990

TEDC1
Tubulin epsilon and delta complex protein 1

2

1

High-throughput

0.628

High

1092992

IQGA3
Ras GTPase-activating-like protein IQGAP3

2

2

High-throughput

0.628

High

1092993

HOOK3
Protein Hook homolog 3

2

1

High-throughput

0.628

High

1092994

LONP2
Lon protease homolog 2, peroxisomal

2

3

High-throughput

0.628

High

1092995

CEP97
Centrosomal protein of 97 kDa

2

2

High-throughput

0.628

High

1092997

MGAP
MAX gene-associated protein

2

2

High-throughput

0.628

High

1093000

RAVR1
Ribonucleoprotein PTB-binding 1

2

10

High-throughput

0.628

High

1093003

ASPM
Abnormal spindle-like microcephaly-associated protein

2

2

High-throughput

0.628

High

1093005

KIF2B
Kinesin-like protein KIF2B

2

6

High-throughput

0.628

High

1093013

ALMS1
Centrosome-associated protein ALMS1

2

10

High-throughput

0.628

High

1093024

MED12
Mediator of RNA polymerase II transcription subunit 12

2

6

High-throughput

0.628

High

1093027

P5CR2
Pyrroline-5-carboxylate reductase 2

2

4

High-throughput

0.628

High

1093039

HAUS8
HAUS augmin-like complex subunit 8

2

1

High-throughput

0.628

High

1093051

DHX35
Probable ATP-dependent RNA helicase DHX35

2

3

High-throughput

0.628

High

1093055

CSR2B
Cysteine-rich protein 2-binding protein

2

2

High-throughput

0.628

High

1093058

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

2

6

High-throughput

0.628

High

1093064

DISC1
Disrupted in schizophrenia 1 protein

2

4

High-throughput

0.628

High

1093076

TRPS1
Zinc finger transcription factor Trps1

2

5

High-throughput

0.628

High

1093077

HOOK1
Protein Hook homolog 1

2

2

High-throughput

0.628

High

1093091

CE164
Centrosomal protein of 164 kDa

2

5

High-throughput

0.628

High

1093093

ZN281
Zinc finger protein 281

2

2

High-throughput

0.628

High

1093068

APC11
Anaphase-promoting complex subunit 11

3

11

Small-scale

0.624

High

1092959

CUL3
Cullin-3

1

4

High-throughput

0.618

High

1092998

CUL9
Cullin-9

1

6

Small-scale

0.618

High

1092999

ANKH1
Ankyrin repeat and KH domain-containing protein 1

2

2

High-throughput

0.611

High

1093053

MAGIX
PDZ domain-containing protein MAGIX

3

6

High-throughput

0.609

High

853784

MK09
Mitogen-activated protein kinase 9

2

4

High-throughput

0.606

High

1092980

CP087
UPF0547 protein C16orf87

3

4

High-throughput

0.604

High

213125

CP110
Centriolar coiled-coil protein of 110 kDa

2

0

High-throughput

0.602

High

322388

HAUS5
HAUS augmin-like complex subunit 5

2

0

High-throughput

0.602

High

946098

MLF1
Myeloid leukemia factor 1

2

0

High-throughput

0.602

High

1086491

TROAP
Tastin

2

0

High-throughput

0.602

High

1092961

ESPL1
Separin

2

0

High-throughput

0.602

High

1092964

IQCB1
IQ calmodulin-binding motif-containing protein 1

2

0

High-throughput

0.602

High

1092965

STIL
SCL-interrupting locus protein

2

0

High-throughput

0.602

High

1092973

PLCH1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

2

0

High-throughput

0.602

High

1092976

ZN318
Zinc finger protein 318

2

0

High-throughput

0.602

High

1092978

HAUS3
HAUS augmin-like complex subunit 3

2

0

High-throughput

0.602

High

1092981

RICTR
Rapamycin-insensitive companion of mTOR

2

0

High-throughput

0.602

High

1092989

HAUS6
HAUS augmin-like complex subunit 6

2

0

High-throughput

0.602

High

1093004

ZN687
Zinc finger protein 687

2

0

High-throughput

0.602

High

1093007

SMG8
Nonsense-mediated mRNA decay factor SMG8

2

0

High-throughput

0.602

High

1093018

SMG7
Nonsense-mediated mRNA decay factor SMG7

2

0

High-throughput

0.602

High

1093037

HAUS7
HAUS augmin-like complex subunit 7

2

0

High-throughput

0.602

High

1093040

TALD3
Protein TALPID3

2

0

High-throughput

0.602

High

1093041

CE295
Centrosomal protein of 295 kDa

2

0

High-throughput

0.602

High

1093054

YYAP1
YY1-associated protein 1

2

0

High-throughput

0.602

High

1093062

MYO5C
Unconventional myosin-Vc

2

0

High-throughput

0.602

High

1093063

4ET
Eukaryotic translation initiation factor 4E transporter

2

0

High-throughput

0.602

High

1093067

MKS1
Tectonic-like complex member MKS1

2

0

High-throughput

0.602

High

1093069

GTSE1
G2 and S phase-expressed protein 1

2

0

High-throughput

0.602

High

1093083

TASOR
Protein TASOR

2

0

High-throughput

0.602

High

919923

PLK1
Serine/threonine-protein kinase PLK1

2

11

High-throughput

0.584

High

979581

H4
Histone H4

2

6

High-throughput

0.584

High

1067249

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.584

High

1093075

ZRAN1
Ubiquitin thioesterase ZRANB1

2

7

High-throughput

0.584

High

176399

ZBTB5
Zinc finger and BTB domain-containing protein 5

2

3

High-throughput

0.574

High

1092977

RSBN1
Lysine-specific demethylase 9

2

1

High-throughput

0.574

High

1092979

PHLB3
Pleckstrin homology-like domain family B member 3

2

1

High-throughput

0.574

High

1092982

SAMD1
Sterile alpha motif domain-containing protein 1

2

2

High-throughput

0.574

High

1092988

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

1

High-throughput

0.574

High

1093009

GP156
Probable G-protein coupled receptor 156

2

1

High-throughput

0.574

High

1093029

DUS3L
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

2

1

High-throughput

0.574

High

1093034

SNX18
Sorting nexin-18

2

3

High-throughput

0.574

High

1093049

ZN644
Zinc finger protein 644

2

1

High-throughput

0.574

High

1093094

SALL2
Sal-like protein 2

2

1

High-throughput

0.574

High

396015

ESR1
Estrogen receptor

2

18

High-throughput

0.571

High

1093020

ESR2
Estrogen receptor beta

2

18

High-throughput

0.571

High

1093026

SH3K1
SH3 domain-containing kinase-binding protein 1

2

11

High-throughput

0.571

High

252056

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.536

High

341933

CEP43
Centrosomal protein 43

1

1

High-throughput

0.536

High

455759

H10
Histone H1.0

1

2

High-throughput

0.536

High

541986

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

725779

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

2

High-throughput

0.536

High

884079

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

927267

ATX1
Ataxin-1

1

2

High-throughput

0.536

High

992155

SKP1
S-phase kinase-associated protein 1

1

2

High-throughput

0.536

High

1092960

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.536

High

1092963

NUMA1
Nuclear mitotic apparatus protein 1

1

3

High-throughput

0.536

High

1092968

H2B2E
Histone H2B type 2-E

1

6

High-throughput

0.536

High

1092969

FHOD3
FH1/FH2 domain-containing protein 3

1

6

High-throughput

0.536

High

1092996

MA7D3
MAP7 domain-containing protein 3

1

6

High-throughput

0.536

High

1093011

KI18A
Kinesin-like protein KIF18A

1

8

High-throughput

0.536

High

1093016

PSPC1
Paraspeckle component 1

1

10

High-throughput

0.536

High

1093021

THRSP
Thyroid hormone-inducible hepatic protein

1

1

High-throughput

0.536

High

1093025

SPSB4
SPRY domain-containing SOCS box protein 4

1

10

High-throughput

0.536

High

1093031

NSUN5
28S rRNA

1

2

High-throughput

0.536

High

1093036

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.536

High

1093046

FA83D
Protein FAM83D

1

1

High-throughput

0.536

High

1093050

RABE2
Rab GTPase-binding effector protein 2

1

4

High-throughput

0.536

High

1093072

E2AK4
eIF-2-alpha kinase GCN2

1

6

High-throughput

0.536

High

1093085

YETS2
YEATS domain-containing protein 2

1

10

High-throughput

0.536

High

1093052

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.518

High

1092956

TADBP
TAR DNA-binding protein 43

1

10

High-throughput

0.515

High

1092972

Q4KMX6
Anaphase-promoting complex subunit 7

1

19

High-throughput

0.514

High

219164

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.513

High

488217

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

1

0

High-throughput

0.513

High

1093001

TRM44
Probable tRNA

1

0

High-throughput

0.513

High

1093014

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

High-throughput

0.513

High

1093017

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.513

High

1093035

GCP6
Gamma-tubulin complex component 6

1

0

High-throughput

0.513

High

1093043

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.513

High

1093056

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.513

High

1093088

CP131
Centrosomal protein of 131 kDa

1

0

High-throughput

0.513

High

1092967

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

7

Small-scale

0.501

High

733920

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

4

High-throughput

0.489

High

1093015

DEP1B
DEP domain-containing protein 1B

1

3

High-throughput

0.489

High

1093057

ZN408
Zinc finger protein 408

1

3

High-throughput

0.489

High

1093060

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

5

High-throughput

0.489

High

1093071

CFA97
Cilia- and flagella-associated protein 97

1

3

High-throughput

0.489

High

1093074

B4GT7
Beta-1,4-galactosyltransferase 7

1

2

High-throughput

0.489

High

1093092

LTOR2
Ragulator complex protein LAMTOR2

1

2

High-throughput

0.489

High

559330

XRCC5
X-ray repair cross-complementing protein 5

1

1

High-throughput

0.481

High

727776

DNJA1
DnaJ homolog subfamily A member 1

1

5

High-throughput

0.481

High

1022155

DAB2
Disabled homolog 2

1

2

High-throughput

0.481

High

129034

MEN1
Menin

1

2

High-throughput

0.479

High

170113

AURKA
Aurora kinase A

1

6

High-throughput

0.479

High

221255

DCX
Neuronal migration protein doublecortin

1

2

Small-scale

0.479

High

241545

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.479

High

252447

DIAP1
Protein diaphanous homolog 1

1

6

High-throughput

0.479

High

259877

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.479

High

345739

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

8

High-throughput

0.479

High

400750

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

442691

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.479

High

573815

CCNB1
G2/mitotic-specific cyclin-B1

1

8

Small-scale

0.479

High

588579

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

700621

PSA5
Proteasome subunit alpha type-5

1

5

Small-scale

0.479

High

714073

PML
Protein PML

1

12

High-throughput

0.479

High

719012

WEE1
Wee1-like protein kinase

1

11

High-throughput

0.479

High

755551

TTK
Dual specificity protein kinase TTK

1

10

Small-scale

0.479

High

788642

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.479

High

799053

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

830650

CCNF
Cyclin-F

1

12

High-throughput

0.479

High

878443

PAXI
Paxillin

1

3

High-throughput

0.479

High

958627

CSN2
COP9 signalosome complex subunit 2

1

6

Small-scale

0.479

High

972381

RS14
Small ribosomal subunit protein uS11

1

1

Small-scale

0.479

High

994198

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

7

Small-scale

0.479

High

998266

H31
Histone H3.1

1

7

High-throughput

0.479

High

1014493

SMAD3
Mothers against decapentaplegic homolog 3

1

6

Small-scale

0.479

High

1026348

HSF1
Heat shock factor protein 1

1

3

High-throughput

0.479

High

1088822

TP53B
TP53-binding protein 1

1

10

High-throughput

0.479

High

1092966

SMAD2
Mothers against decapentaplegic homolog 2

1

6

Small-scale

0.479

High

1092986

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

1092987

PAXI1
PAX-interacting protein 1

1

10

High-throughput

0.479

High

1092991

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

7

Small-scale

0.479

High

1093006

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

High-throughput

0.479

High

1093008

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

12

Small-scale

0.479

High

1093019

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

1093022

REQU
Zinc finger protein ubi-d4

1

13

High-throughput

0.479

High

1093023

CBP
CREB-binding protein

1

17

Small-scale

0.479

High

1093032

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

1093033

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

3

Small-scale

0.479

High

1093042

WWTR1
WW domain-containing transcription regulator protein 1

1

8

High-throughput

0.479

High

1093045

P63
Tumor protein 63

1

4

Small-scale

0.479

High

1093047

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

10

High-throughput

0.479

High

1093048

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.479

High

1093059

PKHA5
Pleckstrin homology domain-containing family A member 5

1

12

Small-scale

0.479

High

1093061

ANLN
Anillin

1

1

High-throughput

0.479

High

1093065

LATS2
Serine/threonine-protein kinase LATS2

1

3

Small-scale

0.479

High

1093070

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

1093073

HECW2
E3 ubiquitin-protein ligase HECW2

1

9

High-throughput

0.479

High

1093090

PHF8
Histone lysine demethylase PHF8

1

6

Small-scale

0.479

High

880911

MTR1B
Melatonin receptor type 1B

1

1

High-throughput

0.464

High

391610

FRIH
Ferritin heavy chain

1

0

High-throughput

0.460

High

890195

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

0

High-throughput

0.460

High

1029818

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

1093095

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

0

High-throughput

0.458

High

224275

BUB3
Mitotic checkpoint protein BUB3

1

10

High-throughput

0.445

High

1092958

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.445

High

1093030

CEP63
Centrosomal protein of 63 kDa

1

2

High-throughput

0.445

High

342169

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.437

High

418964

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.437

High

680337

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

6

High-throughput

0.437

High

96877

E9PDP5
Ankyrin repeat and KH domain containing 1

1

2

High-throughput

0.407

High

1093002

IZUM1
Izumo sperm-egg fusion protein 1

3

0

High-throughput

0.345

High

63754

KRBA1
Protein KRBA1

2

0

High-throughput

0.328

High

70019

YDJC
Carbohydrate deacetylase

2

0

High-throughput

0.328

High

505095

BNIP5
Protein BNIP5

1

0

High-throughput

0.279

Low

617510

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.279

Low

1092974

PR14L
Protein PRR14L

1

0

High-throughput

0.279

Low

1093066

BCD1
Box C/D snoRNA protein 1

1

0

High-throughput

0.279

Low

70007

D11L8
Putative ATP-dependent DNA helicase DDX11-like protein 8

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025