HitPredict

Interactor 1: TNFA (P06804)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: Tnf

Interactor 2: TNR1B (P25119)
Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b)
Gene: Tnfrsf1b

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.52 1.00 0.724

The method score is based on:

Property Details
Experiments 11448951
Identification Methods pull down, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains TNF~TNFR_c6
Common GO terms GO:0006954 - inflammatory response
GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage
GO:0043025 - neuronal cell body
GO:0045121 - membrane raft
GO:0051044 - positive regulation of membrane protein ectodomain proteolysis
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 235
Mm

1 474
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Last updated: 15 Jul 2024