Protein: KS6A1
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)

Gene: KS6A1, RPS6KA1
Organism: Homo sapiens
Interactions: 198
UniProt ID: Q15418

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004711 - ribosomal protein S6 kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

703603

MK01
Mitogen-activated protein kinase 1

14

20

Small-scale

0.981

High

908115

KS6A3
Ribosomal protein S6 kinase alpha-3

6

15

High-throughput

0.949

High

995052

CSK2B
Casein kinase II subunit beta

5

8

High-throughput

0.925

High

1146416

KS6A2
Ribosomal protein S6 kinase alpha-2

5

15

High-throughput

0.925

High

1148336

CDC37
Hsp90 co-chaperone Cdc37

5

15

High-throughput

0.922

High

691751

MK03
Mitogen-activated protein kinase 3

4

20

Small-scale

0.887

High

461505

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.881

High

468399

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.881

High

683460

IKBA
NF-kappa-B inhibitor alpha

3

10

Small-scale

0.878

High

541503

FGFR1
Fibroblast growth factor receptor 1

3

20

Small-scale

0.867

High

440570

FYN
Tyrosine-protein kinase Fyn

3

20

High-throughput

0.855

High

641179

FGFR2
Fibroblast growth factor receptor 2

2

20

High-throughput

0.789

High

857331

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

8

Small-scale

0.770

High

241760

PRKN
E3 ubiquitin-protein ligase parkin

2

16

High-throughput

0.754

High

375543

RASK
GTPase KRas

2

14

High-throughput

0.754

High

1104826

SNTB2
Beta-2-syntrophin

2

20

High-throughput

0.754

High

1122237

SCRIB
Protein scribble homolog

1

7

High-throughput

0.747

High

1148389

PDIP3
Polymerase delta-interacting protein 3

1

6

Small-scale

0.692

High

184640

MK13
Mitogen-activated protein kinase 13

1

20

High-throughput

0.691

High

290316

KS6A4
Ribosomal protein S6 kinase alpha-4

1

16

High-throughput

0.691

High

841011

FRK
Tyrosine-protein kinase FRK

1

20

High-throughput

0.691

High

902268

RB27A
Ras-related protein Rab-27A

1

3

High-throughput

0.691

High

1148337

AMHR2
Anti-Muellerian hormone type-2 receptor

1

4

High-throughput

0.691

High

1148338

PHKG1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

1

16

High-throughput

0.691

High

1148354

TLK2
Serine/threonine-protein kinase tousled-like 2

1

17

High-throughput

0.691

High

1148377

GWL
Serine/threonine-protein kinase greatwall

1

17

High-throughput

0.691

High

187085

PPM1G
Protein phosphatase 1G

1

6

High-throughput

0.656

High

755565

TTK
Dual specificity protein kinase TTK

1

18

High-throughput

0.656

High

1099085

SRSF5
Serine/arginine-rich splicing factor 5

1

11

High-throughput

0.656

High

891570

GSK3B
Glycogen synthase kinase-3 beta

1

20

Small-scale

0.647

High

1148395

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

3

20

Small-scale

0.631

High

890832

TSC2
Tuberin

2

3

Small-scale

0.629

High

1094179

ACACA
Acetyl-CoA carboxylase 1

2

9

High-throughput

0.628

High

729859

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.624

High

630807

RAB4A
Ras-related protein Rab-4A

1

4

High-throughput

0.618

High

161995

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

17

High-throughput

0.618

High

363322

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

373939

RASN
GTPase NRas

1

14

High-throughput

0.618

High

374615

RASH
GTPase HRas

1

10

High-throughput

0.618

High

411982

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

521358

ARAF
Serine/threonine-protein kinase A-Raf

1

20

High-throughput

0.618

High

648518

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

728252

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

High-throughput

0.618

High

884827

PPM1F
Protein phosphatase 1F

1

6

High-throughput

0.618

High

1148333

KS6A1
Ribosomal protein S6 kinase alpha-1

1

15

High-throughput

0.618

High

1148351

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

1148391

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.618

High

1148397

DJC11
DnaJ homolog subfamily C member 11

1

18

High-throughput

0.618

High

1148406

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

1043125

TAP1
Antigen peptide transporter 1

1

0

High-throughput

0.586

High

317847

LTN1
E3 ubiquitin-protein ligase listerin

2

4

High-throughput

0.584

High

1148370

CBP
CREB-binding protein

2

13

Small-scale

0.584

High

897459

TOB1
Protein Tob1

1

1

Small-scale

0.578

High

1028211

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.578

High

660632

IF4B
Eukaryotic translation initiation factor 4B

1

6

Small-scale

0.575

High

1148335

PKN2
Serine/threonine-protein kinase N2

1

18

Small-scale

0.575

High

1148342

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.575

High

1148347

IIGP5
Interferon-inducible GTPase 5

2

2

High-throughput

0.574

High

1148357

MISP
Mitotic interactor and substrate of PLK1

2

2

High-throughput

0.574

High

535096

BIP
Endoplasmic reticulum chaperone BiP

2

15

High-throughput

0.571

High

537203

HSP7C
Heat shock cognate 71 kDa protein

2

8

High-throughput

0.571

High

593114

CREB1
Cyclic AMP-responsive element-binding protein 1

2

6

Small-scale

0.571

High

600817

HSP76
Heat shock 70 kDa protein 6

2

8

High-throughput

0.571

High

1148372

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

7

High-throughput

0.571

High

1148410

CHSP1
Calcium-regulated heat-stable protein 1

1

5

Small-scale

0.568

High

684004

PTN3
Tyrosine-protein phosphatase non-receptor type 3

2

9

Small-scale

0.563

High

1148381

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

2

12

Small-scale

0.563

High

994550

YBOX1
Y-box-binding protein 1

1

6

Small-scale

0.561

High

845649

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.553

High

529850

TAU
Microtubule-associated protein tau

1

20

Small-scale

0.550

High

1050737

MAD1
Max dimerization protein 1

1

7

Small-scale

0.536

High

896532

VASP
Vasodilator-stimulated phosphoprotein

1

7

Small-scale

0.536

High

931241

AT12A
Potassium-transporting ATPase alpha chain 2

1

4

High-throughput

0.536

High

1010304

BASP1
Brain acid soluble protein 1

1

4

High-throughput

0.536

High

1124598

SRC8
Src substrate cortactin

1

8

High-throughput

0.536

High

1148411

TRRAP
Transformation/transcription domain-associated protein

1

20

High-throughput

0.536

High

922312

LIMK2
LIM domain kinase 2

1

9

Small-scale

0.527

High

1104788

SNTA1
Alpha-1-syntrophin

1

20

Small-scale

0.527

High

1118434

SNTB1
Beta-1-syntrophin

1

20

Small-scale

0.527

High

1148348

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

17

Small-scale

0.527

High

1148382

ERBIN
Erbin

1

4

Small-scale

0.527

High

1148390

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

4

Small-scale

0.527

High

1148408

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

17

Small-scale

0.527

High

1022391

IDD
Integral membrane protein DGCR2/IDD

2

3

High-throughput

0.521

High

134448

EF2K
Eukaryotic elongation factor 2 kinase

1

2

Small-scale

0.516

High

705349

GRN
Progranulin

1

0

High-throughput

0.513

High

1148374

F136A
Protein FAM136A

1

0

High-throughput

0.513

High

1148386

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.513

High

1148388

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.513

High

350293

DDAH2
Putative hydrolase DDAH2

1

1

High-throughput

0.508

High

660073

COF1
Cofilin-1

1

2

High-throughput

0.508

High

736919

GBP2
Guanylate-binding protein 2

1

3

High-throughput

0.508

High

899398

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.508

High

927001

ATX3
Ataxin-3

1

2

High-throughput

0.508

High

934651

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.508

High

1023937

EM55
55 kDa erythrocyte membrane protein

1

7

High-throughput

0.508

High

396169

ESR1
Estrogen receptor

1

20

Small-scale

0.501

High

407629

S100B
Protein S100-B

1

10

Small-scale

0.501

High

413886

P53
Cellular tumor antigen p53

1

5

Small-scale

0.501

High

445180

S10A6
Protein S100-A6

1

10

Small-scale

0.501

High

657035

S10A1
Protein S100-A1

1

10

Small-scale

0.501

High

682491

S100P
Protein S100-P

1

10

Small-scale

0.501

High

686816

S10A4
Protein S100-A4

1

10

Small-scale

0.501

High

827794

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.501

High

1102170

ATM
Serine-protein kinase ATM

1

20

Small-scale

0.501

High

1148341

PDCD4
Programmed cell death protein 4

1

3

Small-scale

0.501

High

1148359

RPTOR
Regulatory-associated protein of mTOR

1

14

Small-scale

0.501

High

1148363

DPTOR
DEP domain-containing mTOR-interacting protein

1

3

Small-scale

0.501

High

1148371

BAD
Bcl2-associated agonist of cell death

1

6

Small-scale

0.501

High

1148380

RHG07
Rho GTPase-activating protein 7

1

5

Small-scale

0.501

High

1148396

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

5

Small-scale

0.501

High

1148376

I17RA
Interleukin-17 receptor A

1

3

High-throughput

0.489

High

1148393

PHAX
Phosphorylated adapter RNA export protein

1

0

High-throughput

0.486

High

1148414

CSDC2
Cold shock domain-containing protein C2

1

5

Small-scale

0.484

High

229016

AKAP8
A-kinase anchor protein 8

1

5

Small-scale

0.479

High

238530

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.479

High

281211

CDC45
Cell division control protein 45 homolog

1

1

High-throughput

0.479

High

323721

AP2A2
AP-2 complex subunit alpha-2

1

3

High-throughput

0.479

High

325850

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.479

High

332005

KAT7
Histone acetyltransferase KAT7

1

1

High-throughput

0.479

High

520070

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

588772

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

687242

HMGB2
High mobility group protein B2

1

10

High-throughput

0.479

High

691030

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

695537

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

768266

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

942629

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

8

High-throughput

0.479

High

966342

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

1049314

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1103182

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.479

High

1107543

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

3

High-throughput

0.479

High

1108548

TBB3
Tubulin beta-3 chain

1

17

High-throughput

0.479

High

1148340

WASC4
WASH complex subunit 4

1

2

High-throughput

0.479

High

1148356

CNDG2
Condensin-2 complex subunit G2

1

1

High-throughput

0.479

High

1148358

DHX40
Probable ATP-dependent RNA helicase DHX40

1

2

High-throughput

0.479

High

1148360

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

1

High-throughput

0.479

High

1148361

DOCK4
Dedicator of cytokinesis protein 4

1

6

High-throughput

0.479

High

1148362

ENAH
Protein enabled homolog

1

14

Small-scale

0.479

High

1148366

FRS2
Fibroblast growth factor receptor substrate 2

1

2

High-throughput

0.479

High

1148367

TSC1
Hamartin

1

14

Small-scale

0.479

High

1148369

HDAC2
Histone deacetylase 2

1

9

High-throughput

0.479

High

1148375

AP2M1
AP-2 complex subunit mu

1

6

High-throughput

0.479

High

1148379

SCLT1
Sodium channel and clathrin linker 1

1

15

High-throughput

0.479

High

1148384

DDX50
ATP-dependent RNA helicase DDX50

1

8

High-throughput

0.479

High

1148398

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

2

High-throughput

0.479

High

1148401

AKA7G
A-kinase anchor protein 7 isoform gamma

1

7

High-throughput

0.479

High

1148403

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1148412

DTNA
Dystrobrevin alpha

1

5

High-throughput

0.479

High

1148413

TELO2
Telomere length regulation protein TEL2 homolog

1

1

High-throughput

0.479

High

1148416

COPG1
Coatomer subunit gamma-1

1

5

High-throughput

0.479

High

1148417

AP4B1
AP-4 complex subunit beta-1

1

5

High-throughput

0.479

High

230904

ORC5
Origin recognition complex subunit 5

1

0

High-throughput

0.458

High

377578

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

873732

GSH0
Glutamate--cysteine ligase regulatory subunit

1

0

High-throughput

0.458

High

925539

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.458

High

1121633

MORC3
MORC family CW-type zinc finger protein 3

1

0

High-throughput

0.458

High

1129230

LAGE3
EKC/KEOPS complex subunit LAGE3

1

0

High-throughput

0.458

High

706131

S10A2
Protein S100-A2

1

10

Small-scale

0.457

High

330160

VENTX
Homeobox protein VENTX

1

6

High-throughput

0.445

High

978957

RS6
Small ribosomal subunit protein eS6

1

10

Small-scale

0.445

High

1124814

FLOT2
Flotillin-2

1

6

High-throughput

0.437

High

1148339

INF2
Inverted formin-2

1

3

High-throughput

0.437

High

1148350

GBP6
Guanylate-binding protein 6

1

3

High-throughput

0.437

High

1148352

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.437

High

1148373

NCLN
BOS complex subunit NCLN

1

1

High-throughput

0.437

High

1148383

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.437

High

1148387

LMF2
Lipase maturation factor 2

1

1

High-throughput

0.437

High

1148404

GGA2
ADP-ribosylation factor-binding protein GGA2

1

4

Small-scale

0.437

High

1148409

AP3M1
AP-3 complex subunit mu-1

1

6

High-throughput

0.437

High

1148415

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

2

High-throughput

0.437

High

177381

ARHGB
Rho guanine nucleotide exchange factor 11

1

10

Small-scale

0.408

High

1006070

DLG4
Disks large homolog 4

1

11

Small-scale

0.408

High

1117339

SHRM2
Protein Shroom2

1

6

Small-scale

0.408

High

1148345

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

17

Small-scale

0.408

High

1148353

GRASP
Protein TAMALIN

1

20

Small-scale

0.408

High

1148355

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

15

Small-scale

0.408

High

1148364

LNX1
E3 ubiquitin-protein ligase LNX

1

17

Small-scale

0.408

High

1148378

SNX27
Sorting nexin-27

1

20

Small-scale

0.408

High

1148392

PDZD7
PDZ domain-containing protein 7

1

17

Small-scale

0.408

High

1148399

SNTG2
Gamma-2-syntrophin

1

17

Small-scale

0.408

High

1148400

ARHGC
Rho guanine nucleotide exchange factor 12

1

11

Small-scale

0.408

High

1148402

WHRN
Whirlin

1

20

Small-scale

0.408

High

1148405

NEB1
Neurabin-1

1

18

Small-scale

0.408

High

1148407

PZRN3
E3 ubiquitin-protein ligase PDZRN3

1

18

Small-scale

0.408

High

628410

KLK2
Kallikrein-2

1

3

High-throughput

0.407

High

1148368

HTRA1
Serine protease HTRA1

1

0

Small-scale

0.391

High

62268

GRD2I
Delphilin

1

3

Small-scale

0.373

High

944387

SYJ2B
Synaptojanin-2-binding protein

1

16

Small-scale

0.373

High

1148334

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

20

Small-scale

0.373

High

1148344

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

18

Small-scale

0.373

High

1148349

PZRN4
PDZ domain-containing RING finger protein 4

1

18

Small-scale

0.373

High

1148365

PAR3L
Partitioning defective 3 homolog B

1

14

Small-scale

0.373

High

1148385

GORS1
Golgi reassembly-stacking protein 1

1

1

Small-scale

0.373

High

1148394

GORS2
Golgi reassembly-stacking protein 2

1

1

Small-scale

0.373

High

1148346

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

254288

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

1

0

High-throughput

0.249

Low

1148343

SGMR2
Sigma intracellular receptor 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025