Protein: AT12A
Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump)

Gene: AT12A, ATP12A
Organism: Homo sapiens
Interactions: 181
UniProt ID: P54707

Gene Ontology (top 5):
GO:0005391 - P-type sodium:potassium-exchanging transporter activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005889 - potassium:proton exchanging ATPase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

931220

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

3

16

High-throughput

0.861

High

931228

CLM6
CMRF35-like molecule 6

3

4

High-throughput

0.861

High

565585

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

2

13

High-throughput

0.737

High

249927

NPHN
Nephrin

1

1

High-throughput

0.691

High

420777

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

16

High-throughput

0.691

High

931242

CD226
CD226 antigen

1

6

High-throughput

0.691

High

931293

FXYD6
FXYD domain-containing ion transport regulator 6

1

2

High-throughput

0.691

High

931301

TREM1
Triggering receptor expressed on myeloid cells 1

1

3

High-throughput

0.691

High

212381

SPIT2
Kunitz-type protease inhibitor 2

3

4

High-throughput

0.667

High

720657

AGTR1
Type-1 angiotensin II receptor

3

20

High-throughput

0.667

High

845394

PF2R
Prostaglandin F2-alpha receptor

3

9

High-throughput

0.667

High

931227

TNR9
Tumor necrosis factor receptor superfamily member 9

3

10

High-throughput

0.667

High

931231

SLAF1
Signaling lymphocytic activation molecule

3

6

High-throughput

0.667

High

931262

TARG1
Trafficking regulator of GLUT4 1

3

5

High-throughput

0.667

High

931239

P2Y14
P2Y purinoceptor 14

3

20

High-throughput

0.657

High

268918

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

3

1

High-throughput

0.656

High

931233

NAR3
Ecto-ADP-ribosyltransferase 3

3

1

High-throughput

0.656

High

225445

ITM2A
Integral membrane protein 2A

2

7

High-throughput

0.628

High

638176

S1PR1
Sphingosine 1-phosphate receptor 1

2

20

High-throughput

0.628

High

652179

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

2

7

High-throughput

0.628

High

668983

FPR2
N-formyl peptide receptor 2

2

20

High-throughput

0.628

High

669220

NK1R
Substance-P receptor

2

15

High-throughput

0.628

High

720601

GRPR
Gastrin-releasing peptide receptor

2

16

High-throughput

0.628

High

854521

S15A1
Solute carrier family 15 member 1

2

5

High-throughput

0.628

High

931245

AGK
Acylglycerol kinase, mitochondrial

2

1

High-throughput

0.628

High

931281

MRAP2
Melanocortin-2 receptor accessory protein 2

2

1

High-throughput

0.628

High

931299

PACC1
Proton-activated chloride channel

2

1

High-throughput

0.628

High

931306

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

20

High-throughput

0.628

High

931309

CLC2D
C-type lectin domain family 2 member D

2

8

High-throughput

0.628

High

931315

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

4

High-throughput

0.618

High

420448

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

13

High-throughput

0.618

High

931226

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

2

6

High-throughput

0.611

High

163000

H17B6
17-beta-hydroxysteroid dehydrogenase type 6

3

4

High-throughput

0.609

High

931223

DLK1
Protein delta homolog 1

3

2

High-throughput

0.609

High

931240

DHC24
Delta(24)-sterol reductase

3

3

High-throughput

0.609

High

931251

SUSD4
Sushi domain-containing protein 4

3

1

High-throughput

0.609

High

931257

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

3

3

High-throughput

0.609

High

931258

RETR3
Reticulophagy regulator 3

3

1

High-throughput

0.609

High

931280

WBP1
WW domain-binding protein 1

3

1

High-throughput

0.609

High

931321

SRPRB
Signal recognition particle receptor subunit beta

3

11

High-throughput

0.609

High

931234

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.602

High

931277

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.602

High

931285

FEZ1
Fasciculation and elongation protein zeta-1

2

0

High-throughput

0.602

High

931249

SYRM
Probable arginine--tRNA ligase, mitochondrial

2

0

High-throughput

0.585

High

49444

TM223
Transmembrane protein 223

2

1

High-throughput

0.574

High

931238

TMED2
Transmembrane emp24 domain-containing protein 2

2

5

High-throughput

0.574

High

931268

SPX3
Sugar phosphate exchanger 3

2

2

High-throughput

0.574

High

931273

F174A
Membrane protein FAM174A

2

2

High-throughput

0.574

High

931316

PRG3
Proteoglycan 3

2

1

High-throughput

0.574

High

379963

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

4

High-throughput

0.552

High

475931

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

6

High-throughput

0.541

High

132583

UPK1A
Uroplakin-1a

1

10

High-throughput

0.536

High

139198

UPK2
Uroplakin-2

1

2

High-throughput

0.536

High

141829

ACKR2
Atypical chemokine receptor 2

1

16

High-throughput

0.536

High

164911

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

10

High-throughput

0.536

High

165919

FFAR1
Free fatty acid receptor 1

1

20

High-throughput

0.536

High

178545

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

16

High-throughput

0.536

High

182500

GP182
G-protein coupled receptor 182

1

20

High-throughput

0.536

High

208988

CYB5B
Cytochrome b5 type B

1

4

High-throughput

0.536

High

210384

MTLR
Motilin receptor

1

20

High-throughput

0.536

High

219434

S26A4
Pendrin

1

2

High-throughput

0.536

High

221448

OX2R
Orexin receptor type 2

1

11

High-throughput

0.536

High

230950

TYOBP
TYRO protein tyrosine kinase-binding protein

1

1

High-throughput

0.536

High

351884

S1PR4
Sphingosine 1-phosphate receptor 4

1

20

High-throughput

0.536

High

378617

IL2RA
Interleukin-2 receptor subunit alpha

1

1

High-throughput

0.536

High

638402

FPR1
fMet-Leu-Phe receptor

1

20

High-throughput

0.536

High

640379

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

20

High-throughput

0.536

High

669263

PTAFR
Platelet-activating factor receptor

1

20

High-throughput

0.536

High

688656

NKG2C
NKG2-C type II integral membrane protein

1

9

High-throughput

0.536

High

711546

NK3R
Neuromedin-K receptor

1

13

High-throughput

0.536

High

723676

NTR1
Neurotensin receptor type 1

1

16

High-throughput

0.536

High

732962

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

6

High-throughput

0.536

High

733316

CCR1
C-C chemokine receptor type 1

1

19

High-throughput

0.536

High

771106

APJ
Apelin receptor

1

16

High-throughput

0.536

High

820551

GPV
Platelet glycoprotein V

1

10

High-throughput

0.536

High

832394

OPRX
Nociceptin receptor

1

16

High-throughput

0.536

High

833812

P2RY2
P2Y purinoceptor 2

1

20

High-throughput

0.536

High

835260

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

6

High-throughput

0.536

High

867608

GPR12
G-protein coupled receptor 12

1

17

High-throughput

0.536

High

867952

GLR
Glucagon receptor

1

6

High-throughput

0.536

High

907004

CCR6
C-C chemokine receptor type 6

1

17

High-throughput

0.536

High

914524

EFNA5
Ephrin-A5

1

2

High-throughput

0.536

High

931221

PAR2
Proteinase-activated receptor 2

1

20

High-throughput

0.536

High

931222

X3CL1
Fractalkine

1

1

High-throughput

0.536

High

931225

S25A3
Solute carrier family 25 member 3

1

5

High-throughput

0.536

High

931230

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

9

High-throughput

0.536

High

931232

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

20

High-throughput

0.536

High

931236

NAA30
N-alpha-acetyltransferase 30

1

1

High-throughput

0.536

High

931237

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

4

High-throughput

0.536

High

931241

KS6A1
Ribosomal protein S6 kinase alpha-1

1

4

High-throughput

0.536

High

931255

SO4C1
Solute carrier organic anion transporter family member 4C1

1

1

High-throughput

0.536

High

931256

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

11

High-throughput

0.536

High

931259

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

20

High-throughput

0.536

High

931260

INLR1
Interferon lambda receptor 1

1

1

High-throughput

0.536

High

931263

S22AF
Solute carrier family 22 member 15

1

3

High-throughput

0.536

High

931266

KC1AL
Casein kinase I isoform alpha-like

1

5

High-throughput

0.536

High

931274

SPP2B
Signal peptide peptidase-like 2B

1

5

High-throughput

0.536

High

931276

RAB2B
Ras-related protein Rab-2B

1

9

High-throughput

0.536

High

931286

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

1

High-throughput

0.536

High

931289

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

7

High-throughput

0.536

High

931291

GPR88
G protein-coupled receptor 88

1

1

High-throughput

0.536

High

931292

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

3

High-throughput

0.536

High

931294

TSN10
Tetraspanin-10

1

9

High-throughput

0.536

High

931295

CXL16
C-X-C motif chemokine 16

1

1

High-throughput

0.536

High

931300

CHODL
Chondrolectin

1

3

High-throughput

0.536

High

931302

KCMB3
Calcium-activated potassium channel subunit beta-3

1

2

High-throughput

0.536

High

931304

GPR84
G-protein coupled receptor 84

1

5

High-throughput

0.536

High

931305

KLH11
Kelch-like protein 11

1

1

High-throughput

0.536

High

931307

HCST
Hematopoietic cell signal transducer

1

1

High-throughput

0.536

High

931313

PRND
Prion-like protein doppel

1

1

High-throughput

0.536

High

931318

RN115
E3 ubiquitin-protein ligase RNF115

1

4

High-throughput

0.536

High

931319

PCDG7
Protocadherin gamma-A7

1

8

High-throughput

0.536

High

656082

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

High-throughput

0.518

High

931303

ACKR4
Atypical chemokine receptor 4

1

16

High-throughput

0.515

High

303679

JTB
Protein JTB

1

0

High-throughput

0.513

High

407162

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

High-throughput

0.513

High

470272

NEP
Neprilysin

1

0

Small-scale

0.513

High

723221

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

0

High-throughput

0.513

High

873852

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.513

High

931244

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.513

High

931248

RTP2
Receptor-transporting protein 2

1

0

High-throughput

0.513

High

931288

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.513

High

931290

CEP41
Centrosomal protein of 41 kDa

1

0

High-throughput

0.513

High

931312

PILRB
Paired immunoglobulin-like type 2 receptor beta

1

0

High-throughput

0.513

High

931317

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.513

High

49778

CLRN2
Clarin-2

1

1

High-throughput

0.489

High

137688

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.489

High

229223

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

2

High-throughput

0.489

High

230696

NKG2F
NKG2-F type II integral membrane protein

1

3

High-throughput

0.489

High

253827

TPST2
Protein-tyrosine sulfotransferase 2

1

2

High-throughput

0.489

High

298845

LYZL6
Lysozyme-like protein 6

1

2

High-throughput

0.489

High

327209

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.489

High

552177

ADT3
ADP/ATP translocase 3

1

4

High-throughput

0.489

High

634751

GRAH
Granzyme H

1

4

High-throughput

0.489

High

647471

UD14
UDP-glucuronosyltransferase 1A4

1

1

High-throughput

0.489

High

931229

SIA4A
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

1

4

High-throughput

0.489

High

931235

LAGE3
EKC/KEOPS complex subunit LAGE3

1

2

High-throughput

0.489

High

931250

FAXC
Failed axon connections homolog

1

2

High-throughput

0.489

High

931267

RN149
E3 ubiquitin-protein ligase RNF149

1

5

High-throughput

0.489

High

931269

LRN4L
LRRN4 C-terminal-like protein

1

1

High-throughput

0.489

High

931271

B3GN7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

1

4

High-throughput

0.489

High

931275

HUMMR
Protein MGARP

1

1

High-throughput

0.489

High

931284

SEC62
Translocation protein SEC62

1

4

High-throughput

0.489

High

931287

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

16

High-throughput

0.489

High

931296

G3ST2
Galactose-3-O-sulfotransferase 2

1

1

High-throughput

0.489

High

931311

DKKL1
Dickkopf-like protein 1

1

1

High-throughput

0.489

High

931323

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

2

High-throughput

0.489

High

158561

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

3

High-throughput

0.479

High

411647

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

133735

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

931272

O10G2
Olfactory receptor 10G2

1

0

High-throughput

0.458

High

931320

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.458

High

97125

E9PNY5
Fc gamma receptor IIIb

1

1

High-throughput

0.445

High

380527

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

11

High-throughput

0.445

High

405940

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

931261

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.437

High

931310

XPO7
Exportin-7

1

2

High-throughput

0.437

High

931314

TRI33
E3 ubiquitin-protein ligase TRIM33

1

4

High-throughput

0.437

High

931247

Q5J1K9
Mono-ADP-ribosyltransferase 3 variant Ia

1

1

High-throughput

0.407

High

931297

TRABD
TraB domain-containing protein

3

0

High-throughput

0.347

High

931243

ODFP4
Outer dense fiber protein 4

2

0

High-throughput

0.328

High

931253

IIGP5
Interferon-inducible GTPase 5

2

0

High-throughput

0.328

High

388705

C1QB
Complement C1q subcomponent subunit B

2

0

High-throughput

0.318

High

377340

NPY
Pro-neuropeptide Y [Cleaved into: Neuropeptide Y

1

0

High-throughput

0.282

High

168081

TIM23
Mitochondrial import inner membrane translocase subunit Tim23

1

0

High-throughput

0.279

Low

226965

ENSA
Alpha-endosulfine

1

0

High-throughput

0.279

Low

931224

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.279

Low

931246

KCP3
Keratinocyte-associated protein 3

1

0

High-throughput

0.279

Low

931252

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.279

Low

931254

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.279

Low

931264

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.279

Low

931265

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.279

Low

931270

WFD11
Protein WFDC11

1

0

High-throughput

0.279

Low

931278

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

931279

NUD16
U8 snoRNA-decapping enzyme

1

0

High-throughput

0.279

Low

931282

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

931283

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

931298

EMRE
Essential MCU regulator, mitochondrial

1

0

High-throughput

0.279

Low

931308

NAT8B
N-acetyltransferase 8B

1

0

High-throughput

0.279

Low

931322

HS3S4
Heparan sulfate glucosamine 3-O-sulfotransferase 4

1

0

High-throughput

0.279

Low

931324

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025