HitPredict

Interactor 1: TY3H (P07101)
Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH)
Gene: TH

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	34031189, 19801645, 18181650
Identification Methods	pull down, surface plasmon resonance
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019904 - protein domain specific binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 528 Hs			1 245
+	Hs
		421372 TY3H_HUMAN (1-528): 0: 862: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Rn
		378419 TY3H_RAT (1-527): 0: 796: 83.90		1433Z_RAT (1-245): 3.48e-145: 407: 99.59
+	Hs
		421377 TY3H_HUMAN (1-528): 0: 862: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		570814 TPH1_HUMAN (114-527): 0: 671: 50.24		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		909787 TPH2_HUMAN (114-527): 0: 647: 50.71		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18