HitPredict

Interactor 1: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Interactor 2: CALR3 (Q96L12)
Calreticulin-3 (Calreticulin-2) (Calsperin)
Gene: CALR3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31056421, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Calreticulin~Thioredoxin_6
Common GO terms	GO:0005788 - endoplasmic reticulum lumen GO:0006457 - protein folding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 384
+	Hs
		671897 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Mm
		1322122 PDILT_MOUSE (22-489): 1.48e-94: 300: 30.43		CALR3_MOUSE (1-384): 0: 523: 82.60
+	Hs
		423150 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		653491 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Dm
		667013 PDI_DROME (2-477): 3.62e-130: 389: 54.93		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	Dm
		667020 Q3YMU0_DROME (2-491): 6.16e-107: 329: 31.80		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	Hs
		654099 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Rn
		514119 PDIA3_RAT (4-495): 3.59e-119: 361: 31.50		CALX_RAT (16-357): 1.96e-122: 367: 26.97
+	Hs
		1296643 ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		531950 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		1220455 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Mm
		852408 PDILT_MOUSE (22-489): 1.48e-94: 300: 30.43		CLGN_MOUSE (20-336): 2.44e-111: 340: 26.28
+	Hs
		653575 PDIA2_HUMAN (380-507): 1.39e-25: 111: 26.52		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		531728 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		653711 ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		653650 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	At
		137900 PDI21_ARATH (384-474): 4.26e-12: 69.3: 36.56		CALR1_ARATH (3-341): 3.11e-144: 417: 38.94
+	Hs
		531729 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		654706 ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		654519 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73