HitPredict

Interactor 1: FES (P07332)
Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)
Gene: FES

Interactor 2: BCR (P11274)
Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)
Gene: BCR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	10706130, 7529874
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	C2~SH2
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 1271
+	Hs
		337325 ABL1_HUMAN (368-820): 1.22e-152: 477: 32.35		BCR_HUMAN (1-1271): 0: 1005: 100.00
+	Hs
		442768 HCK_HUMAN (335-817): 1.75e-156: 468: 29.16		BCR_HUMAN (1-1271): 0: 1005: 100.00
+	Hs
		337453 ABL1_HUMAN (368-820): 1.22e-152: 477: 32.35		ABR_HUMAN (419-1271): 0: 567: 66.47
+	Hs
		561393 FER_HUMAN (1-820): 0: 874: 50.30		RHG21_HUMAN (1049-1216): 3.06e-23: 109: 40.00
+	Hs
		561401 FER_HUMAN (1-820): 0: 874: 50.30		RHG23_HUMAN (1052-1216): 1.59e-21: 103: 38.92
+	Hs
		433726 LYN_HUMAN (368-817): 1.6e-152: 457: 30.80		ARHG5_HUMAN (95-862): 8.55e-82: 297: 14.49
+	Hs
		337333 ABL1_HUMAN (368-820): 1.22e-152: 477: 32.35		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		433781 LYN_HUMAN (368-817): 1.6e-152: 457: 30.80		ITSN1_HUMAN (74-927): 1.53e-78: 287: 13.61
+	Hs
		548654 TEC_HUMAN (325-821): 7.35e-154: 465: 28.17		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Hs
		411673 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		FGD1_HUMAN (162-971): 1.22e-77: 279: 13.57
+	Hs
		411580 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		VAV_HUMAN (393-1092): 5.12e-77: 275: 12.29
+	Ce
		106680 SRC1_CAEEL (400-816): 2.87e-153: 460: 30.96		SYD1_CAEEL (899-1261): 6.38e-72: 262: 22.37
+	Hs
		299230 LYN_HUMAN (368-817): 1.6e-152: 457: 30.80		FARP2_HUMAN (356-812): 1.08e-68: 253: 18.26
+	Hs
		224698 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		KALRN_HUMAN (457-1087): 1.21e-57: 222: 14.20
+	Hs
		279830 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		TRIO_HUMAN (482-1040): 8.74e-54: 209: 12.72
+	Hs
		279832 LYN_HUMAN (368-817): 1.6e-152: 457: 30.80		TRIO_HUMAN (482-1040): 8.74e-54: 209: 12.72
+	Ce
		220207 SRC2_CAEEL (400-817): 1.13e-157: 470: 32.35		TG325_CAEEL (1039-1212): 9.19e-24: 110: 37.93
+	Hs
		442834 HCK_HUMAN (335-817): 1.75e-156: 468: 29.16		RBP1_HUMAN (1051-1211): 4.99e-20: 98.2: 34.55
+	Hs
		411755 LCK_HUMAN (382-817): 1.65e-152: 457: 31.82		RHG21_HUMAN (1049-1216): 3.06e-23: 109: 40.00
+	Hs
		433814 LYN_HUMAN (368-817): 1.6e-152: 457: 30.80		RHG21_HUMAN (1049-1216): 3.06e-23: 109: 40.00