Interactor 1: EDN1 (P05305)
Endothelin-1 (Preproendothelin-1) (PPET1) [Cleaved into: Endothelin-1 (ET-1); Big endothelin-1]
Gene: EDN1
Interactor 2: EDNRB (P24530)
Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type)
Gene: EDNRB
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.38 | 1.00 | 0.618 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 23597562 |
| Identification Methods | scintillation proximity assay |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | 7tm_1~Endothelin |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0006885 - regulation of pH GO:0007166 - cell surface receptor signaling pathway GO:0007200 - phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007204 - positive regulation of cytosolic calcium ion concentration and 13 others more... |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
