HitPredict - High confidence protein-protein interactions

Interactor 1: HEXB (P07686)
Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]
Gene: HEXB

Interactor 2: HEXB (P07686)
Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]
Gene: HEXB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	12706724
Identification Methods	x-ray crystallography
Interaction Type	association

Property	Details
Interacting Pfam domains	Glyco_hydro_20~Glyco_hydro_20, Glyco_hydro_20~Glycohydro_20b2, Glycohydro_20b2~Glycohydro_20b2
Common GO terms	GO:0001501 - skeletal system development GO:0001669 - acrosomal vesicle GO:0004563 - beta-N-acetylhexosaminidase activity GO:0005576 - extracellular region GO:0005764 - lysosome and 32 others more... GO:0006689 - ganglioside catabolic process GO:0006874 - intracellular calcium ion homeostasis GO:0007040 - lysosome organization GO:0007338 - single fertilization GO:0007341 - penetration of zona pellucida GO:0007605 - sensory perception of sound GO:0007626 - locomotory behavior GO:0008049 - male courtship behavior GO:0008360 - regulation of cell shape GO:0008375 - acetylglucosaminyltransferase activity GO:0008654 - phospholipid biosynthetic process GO:0009313 - oligosaccharide catabolic process GO:0016020 - membrane GO:0019915 - lipid storage GO:0030203 - glycosaminoglycan metabolic process GO:0030207 - chondroitin sulfate catabolic process GO:0030209 - dermatan sulfate catabolic process GO:0030214 - hyaluronan catabolic process GO:0035578 - azurophil granule lumen GO:0042552 - myelination GO:0042582 - azurophil granule GO:0043202 - lysosomal lumen GO:0043615 - astrocyte cell migration GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0048477 - oogenesis GO:0050885 - neuromuscular process controlling balance GO:0051651 - maintenance of location in cell GO:0060473 - cortical granule GO:0070050 - neuron cellular homeostasis GO:0070062 - extracellular exosome GO:0102148 - N-acetyl-beta-D-galactosaminidase activity GO:1905379 - beta-N-acetylhexosaminidase complex
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	556
Hs

1	556

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Last updated: 15 Jul 2024