HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: NR1I3 (Q14994)
Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67)
Gene: NR1I3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29101097, 22939624, 24224465
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 352
+	Hs
		265845 HS90A_HUMAN (1-732): 0: 1087: 100.00		NR1I2_HUMAN (8-351): 3.57e-105: 317: 40.55
+	Hs
		368832 HS90A_HUMAN (1-732): 0: 1087: 100.00		ESR1_HUMAN (2-351): 1.82e-94: 294: 21.66
+	Hs
		265846 HS90B_HUMAN (19-732): 0: 1059: 86.13		NR1I2_HUMAN (8-351): 3.57e-105: 317: 40.55
+	Hs
		437840 HS90B_HUMAN (19-732): 0: 1059: 86.13		VDR_HUMAN (8-351): 4.64e-105: 316: 33.74
+	Hs
		320155 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERR2_HUMAN (7-351): 9.37e-93: 285: 24.50
+	Hs
		431801 HS90A_HUMAN (1-732): 0: 1087: 100.00		NR1H3_HUMAN (8-351): 1.28e-92: 285: 29.61
+	Hs
		438177 HS90B_HUMAN (19-732): 0: 1059: 86.13		NR1I3_HUMAN (1-352): 1.93e-102: 307: 100.00
+	Hs
		432122 HS90A_HUMAN (1-732): 0: 1087: 100.00		ESR2_HUMAN (2-352): 4.23e-88: 276: 21.76
+	Hs
		368839 HS90B_HUMAN (19-732): 0: 1059: 86.13		ESR1_HUMAN (2-351): 1.82e-94: 294: 21.66
+	Hs
		320158 HS90B_HUMAN (19-732): 0: 1059: 86.13		ERR2_HUMAN (7-351): 9.37e-93: 285: 24.50
+	Hs
		438124 HS90B_HUMAN (19-732): 0: 1059: 86.13		NR1H3_HUMAN (8-351): 1.28e-92: 285: 29.61
+	Hs
		437901 HS90B_HUMAN (19-732): 0: 1059: 86.13		NR4A1_HUMAN (2-351): 1.9e-90: 284: 23.86
+	Mm
		193208 HS90B_MOUSE (19-732): 0: 1063: 86.98		NR1I3_MOUSE (2-352): 1.46e-88: 271: 73.22
+	Hs
		538114 ENPL_HUMAN (14-701): 0: 898: 46.78		RXRB_HUMAN (8-351): 2.38e-101: 310: 23.99
+	Hs
		368916 ENPL_HUMAN (14-701): 0: 898: 46.78		ESR1_HUMAN (2-351): 1.82e-94: 294: 21.66
+	Hs
		538103 ENPL_HUMAN (14-701): 0: 898: 46.78		NR4A1_HUMAN (2-351): 1.9e-90: 284: 23.86
+	Hs
		538337 ENPL_HUMAN (14-701): 0: 898: 46.78		ESR2_HUMAN (2-352): 4.23e-88: 276: 21.76
+	Hs
		1123455 H90B3_HUMAN (19-732): 0: 728: 65.41		ESR2_HUMAN (2-352): 4.23e-88: 276: 21.76