Protein: ITB2
Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)

Gene: ITB2, ITGB2
Organism: Homo sapiens
Interactions: 73
UniProt ID: P05107

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0001774 - microglial cell activation
GO:0001851 - complement component C3b binding
GO:0002523 - leukocyte migration involved in inflammatory response
GO:0005178 - integrin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

424053

ITAM
Integrin alpha-M

3

20

Small-scale

0.839

High

424058

ITAX
Integrin alpha-X

2

20

Small-scale

0.800

High

424110

TLN2
Talin-2

1

20

Small-scale

0.747

High

424049

ICAM1
Intercellular adhesion molecule 1

5

6

Small-scale

0.710

High

424082

CYH1
Cytohesin-1

4

1

Small-scale

0.696

High

424057

ITAL
Integrin alpha-L

1

20

Small-scale

0.665

High

362580

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.653

High

424088

NT2NA
Notch homolog 2 N-terminal-like protein A

4

17

High-throughput

0.644

High

424075

ITAD
Integrin alpha-D

1

20

Small-scale

0.618

High

424084

CD226
CD226 antigen

1

8

Small-scale

0.618

High

424101

JAM3
Junctional adhesion molecule C

1

9

Small-scale

0.618

High

70080

CRTP1
Cysteine-rich tail protein 1

2

3

High-throughput

0.606

High

295668

UPK1B
Uroplakin-1b

2

20

High-throughput

0.606

High

424081

K1H1
Keratin, type I cuticular Ha1

2

7

High-throughput

0.606

High

424087

ATL4
ADAMTS-like protein 4

2

1

High-throughput

0.606

High

424068

RACK1
Small ribosomal subunit protein RACK1

1

6

Small-scale

0.586

High

424095

RANB9
Ran-binding protein 9

1

5

Small-scale

0.586

High

424060

1433B
14-3-3 protein beta/alpha

2

4

Small-scale

0.584

High

424063

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.584

High

424090

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

0

High-throughput

0.580

High

424093

T4S18
Transmembrane 4 L6 family member 18

2

0

High-throughput

0.580

High

424099

APOL2
Apolipoprotein L2

2

0

High-throughput

0.580

High

424103

MS4A7
Membrane-spanning 4-domains subfamily A member 7

2

0

High-throughput

0.580

High

424061

RADI
Radixin

1

8

Small-scale

0.561

High

424073

UPAR
Urokinase plasminogen activator surface receptor

2

0

Small-scale

0.559

High

424066

KR108
Keratin-associated protein 10-8

2

20

High-throughput

0.553

High

424098

DOK1
Docking protein 1

1

4

Small-scale

0.553

High

424078

FHL2
Four and a half LIM domains protein 2

1

9

Small-scale

0.552

High

424092

CSN5
COP9 signalosome complex subunit 5

1

1

Small-scale

0.552

High

424064

CD151
CD151 antigen

1

20

High-throughput

0.536

High

424071

AMPD3
AMP deaminase 3

1

1

High-throughput

0.536

High

424091

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.536

High

424094

SREC2
Scavenger receptor class F member 2

1

11

High-throughput

0.536

High

424102

TX101
Testis-expressed protein 101

1

2

High-throughput

0.536

High

369804

CO3
Complement C3

1

2

Small-scale

0.527

High

362118

ABL1
Tyrosine-protein kinase ABL1

1

15

Small-scale

0.515

High

424083

BGH3
Transforming growth factor-beta-induced protein ig-h3

1

1

Small-scale

0.515

High

424100

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.513

High

424106

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.513

High

370393

KNG1
Kininogen-1

1

3

Small-scale

0.501

High

424048

KPCG
Protein kinase C gamma type

1

16

Small-scale

0.501

High

424050

KPCB
Protein kinase C beta type

1

15

Small-scale

0.501

High

424056

KPCA
Protein kinase C alpha type

1

15

Small-scale

0.501

High

424072

KPCE
Protein kinase C epsilon type

1

12

Small-scale

0.501

High

424074

KPCD
Protein kinase C delta type

1

15

Small-scale

0.501

High

424104

SHRPN
Sharpin

1

2

Small-scale

0.489

High

210677

KLK10
Kallikrein-10

1

7

High-throughput

0.489

High

424051

LYN
Tyrosine-protein kinase Lyn

1

15

Small-scale

0.479

High

424054

PLSL
Plastin-2

1

16

High-throughput

0.479

High

424055

VAV
Proto-oncogene vav

1

3

Small-scale

0.479

High

424059

1433T
14-3-3 protein theta

1

4

Small-scale

0.479

High

424062

MYH9
Myosin-9

1

5

Small-scale

0.479

High

424067

1433Z
14-3-3 protein zeta/delta

1

4

Small-scale

0.479

High

424069

X3CL1
Fractalkine

1

4

Small-scale

0.479

High

424070

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

20

Small-scale

0.479

High

424076

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

Small-scale

0.479

High

424079

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.479

High

424080

ICAM4
Intercellular adhesion molecule 4

1

3

Small-scale

0.479

High

424052

NT2NC
Notch homolog 2 N-terminal-like protein C

1

18

High-throughput

0.470

High

424077

KEAP1
Kelch-like ECH-associated protein 1

1

1

High-throughput

0.470

High

424085

FX4L6
Forkhead box protein D4-like 6

1

1

High-throughput

0.470

High

338676

VNN2
Pantetheine hydrolase VNN2

1

0

Small-scale

0.458

High

387206

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.458

High

424096

CYH2
Cytohesin-2

1

1

Small-scale

0.457

High

424089

CD177
CD177 antigen

1

2

Small-scale

0.445

High

424107

FBX2
F-box only protein 2

1

13

High-throughput

0.445

High

460

NBPFJ
NBPF family member NBPF19

1

7

High-throughput

0.439

High

424086

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.407

High

424105

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

424108

SCML1
Sex comb on midleg-like protein 1

2

0

High-throughput

0.316

High

424109

CSN3
COP9 signalosome complex subunit 3

1

0

Small-scale

0.288

High

424097

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.279

Low

424065

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025