Protein: RHDF2
Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6)

Gene: RHDF2, RHBDF2
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q6PJF5

Gene Ontology (top 5):
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0005789 - endoplasmic reticulum membrane
GO:0005796 - Golgi lumen
GO:0005886 - plasma membrane
GO:0015031 - protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

845439

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

1

High-throughput

0.667

High

1155152

EREP1
Endosomal transmembrane epsin interactor 1

3

2

High-throughput

0.667

High

1245122

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

2

3

High-throughput

0.628

High

1245077

RHDF2
Inactive rhomboid protein 2

1

3

High-throughput

0.618

High

665042

IL4RA
Interleukin-4 receptor subunit alpha

2

0

High-throughput

0.602

High

1142497

PDCD1
Programmed cell death protein 1

2

0

High-throughput

0.602

High

788944

TGFR2
TGF-beta receptor type-2

2

5

High-throughput

0.601

High

1049435

1433F
14-3-3 protein eta

2

3

High-throughput

0.601

High

1245115

BSCL2
Seipin

2

1

High-throughput

0.601

High

1245163

KCNE3
Potassium voltage-gated channel subfamily E member 3

2

1

High-throughput

0.601

High

182605

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

190400

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.536

High

572936

INSRR
Insulin receptor-related protein

1

1

High-throughput

0.536

High

850785

KI2L1
Killer cell immunoglobulin-like receptor 2DL1

1

3

High-throughput

0.536

High

1086014

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.536

High

1161845

AMHR2
Anti-Muellerian hormone type-2 receptor

1

6

High-throughput

0.536

High

1245080

BT2A1
Butyrophilin subfamily 2 member A1

1

1

High-throughput

0.536

High

1245100

IGDC4
Immunoglobulin superfamily DCC subclass member 4

1

1

High-throughput

0.536

High

1245105

AQP3
Aquaporin-3

1

5

High-throughput

0.536

High

1245121

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

3

High-throughput

0.536

High

1245140

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

1

1

High-throughput

0.536

High

1245151

CLC4A
C-type lectin domain family 4 member A

1

1

High-throughput

0.536

High

1245160

PCDB3
Protocadherin beta-3

1

2

High-throughput

0.536

High

322532

SLIK3
SLIT and NTRK-like protein 3

1

3

High-throughput

0.515

High

252687

TSN3
Tetraspanin-3

1

0

High-throughput

0.513

High

475984

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

0

High-throughput

0.513

High

1007870

X3CL1
Fractalkine

1

0

High-throughput

0.513

High

1126312

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1203695

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1212105

TRML2
Trem-like transcript 2 protein

1

0

High-throughput

0.513

High

1244987

TRAT1
T-cell receptor-associated transmembrane adapter 1

1

0

High-throughput

0.513

High

1245087

TCAM2
TIR domain-containing adapter molecule 2

1

0

High-throughput

0.513

High

1245104

BSND
Barttin

1

0

High-throughput

0.513

High

1245110

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

0

High-throughput

0.513

High

1245118

OPALI
Opalin

1

0

High-throughput

0.513

High

1245139

GPC5B
G-protein coupled receptor family C group 5 member B

1

0

High-throughput

0.513

High

1245146

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

0

High-throughput

0.513

High

1245152

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.512

High

682523

S100P
Protein S100-P

1

6

High-throughput

0.489

High

706175

S10A2
Protein S100-A2

1

6

High-throughput

0.489

High

996991

TBA4A
Tubulin alpha-4A chain

1

1

High-throughput

0.489

High

1245092

NRSN1
Neurensin-1

1

1

High-throughput

0.489

High

1245113

F131C
Protein FAM131C

1

1

High-throughput

0.489

High

1245154

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

High-throughput

0.489

High

127112

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.479

High

192265

YKT6
Synaptobrevin homolog YKT6

1

3

High-throughput

0.479

High

217461

E41L2
Band 4.1-like protein 2

1

5

High-throughput

0.479

High

286220

CSDE1
Cold shock domain-containing protein E1

1

1

High-throughput

0.479

High

324349

SLIK5
SLIT and NTRK-like protein 5

1

3

High-throughput

0.479

High

329550

STBD1
Starch-binding domain-containing protein 1

1

1

High-throughput

0.479

High

333054

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

6

High-throughput

0.479

High

343396

SNP29
Synaptosomal-associated protein 29

1

1

High-throughput

0.479

High

363436

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

374005

RASN
GTPase NRas

1

3

High-throughput

0.479

High

375633

RASK
GTPase KRas

1

3

High-throughput

0.479

High

431836

ITB1
Integrin beta-1

1

4

High-throughput

0.479

High

469108

SRPRA
Signal recognition particle receptor subunit alpha

1

1

High-throughput

0.479

High

548517

MPRI
Cation-independent mannose-6-phosphate receptor

1

3

High-throughput

0.479

High

875693

PRC2A
Protein PRRC2A

1

1

High-throughput

0.479

High

903962

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

906082

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

1

High-throughput

0.479

High

914434

EFNB2
Ephrin-B2

1

2

High-throughput

0.479

High

933326

IF5
Eukaryotic translation initiation factor 5

1

1

High-throughput

0.479

High

1008434

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

1

High-throughput

0.479

High

1022882

EFNB1
Ephrin-B1

1

2

High-throughput

0.479

High

1039956

AKA12
A-kinase anchor protein 12

1

2

High-throughput

0.479

High

1040317

DYST
Dystonin

1

3

High-throughput

0.479

High

1047587

NOTC2
Neurogenic locus notch homolog protein 2

1

2

High-throughput

0.479

High

1058474

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.479

High

1068237

AHNK
Neuroblast differentiation-associated protein AHNAK

1

1

High-throughput

0.479

High

1097803

STX5
Syntaxin-5

1

1

High-throughput

0.479

High

1120746

DSG2
Desmoglein-2

1

2

High-throughput

0.479

High

1124625

SRC8
Src substrate cortactin

1

3

High-throughput

0.479

High

1152801

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

1

High-throughput

0.479

High

1154652

VAMP3
Vesicle-associated membrane protein 3

1

2

High-throughput

0.479

High

1218405

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

1

High-throughput

0.479

High

1245081

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

2

High-throughput

0.479

High

1245083

LYRIC
Protein LYRIC

1

1

High-throughput

0.479

High

1245084

KTN1
Kinectin

1

3

High-throughput

0.479

High

1245086

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

1

High-throughput

0.479

High

1245088

VRK2
Serine/threonine-protein kinase VRK2

1

1

High-throughput

0.479

High

1245093

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

1245096

EHBP1
EH domain-binding protein 1

1

1

High-throughput

0.479

High

1245097

VANG1
Vang-like protein 1

1

3

High-throughput

0.479

High

1245099

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

1

High-throughput

0.479

High

1245102

CANT1
Soluble calcium-activated nucleotidase 1

1

1

High-throughput

0.479

High

1245106

UBXN4
UBX domain-containing protein 4

1

2

High-throughput

0.479

High

1245111

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.479

High

1245112

LRC59
Leucine-rich repeat-containing protein 59

1

5

High-throughput

0.479

High

1245117

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1245119

ERBIN
Erbin

1

3

High-throughput

0.479

High

1245120

CLCC1
Chloride channel CLIC-like protein 1

1

1

High-throughput

0.479

High

1245123

COR1B
Coronin-1B

1

1

High-throughput

0.479

High

1245124

ESYT1
Extended synaptotagmin-1

1

2

High-throughput

0.479

High

1245127

LSG1
Large subunit GTPase 1 homolog

1

1

High-throughput

0.479

High

1245129

TMX1
Thioredoxin-related transmembrane protein 1

1

4

High-throughput

0.479

High

1245132

E41L5
Band 4.1-like protein 5

1

4

High-throughput

0.479

High

1245133

SEC12
Guanine nucleotide-exchange factor SEC12

1

4

High-throughput

0.479

High

1245134

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

3

High-throughput

0.479

High

1245135

JPH1
Junctophilin-1

1

1

High-throughput

0.479

High

1245137

RTN4
Reticulon-4

1

3

High-throughput

0.479

High

1245142

VAPA
Vesicle-associated membrane protein-associated protein A

1

6

High-throughput

0.479

High

1245144

RRBP1
Ribosome-binding protein 1

1

3

High-throughput

0.479

High

1245145

COPG2
Coatomer subunit gamma-2

1

2

High-throughput

0.479

High

1245150

VANG2
Vang-like protein 2

1

3

High-throughput

0.479

High

1245156

E41L3
Band 4.1-like protein 3

1

4

High-throughput

0.479

High

1245158

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

1

High-throughput

0.479

High

1245161

CD2AP
CD2-associated protein

1

1

High-throughput

0.479

High

1245162

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

1

High-throughput

0.479

High

1245164

TX264
Testis-expressed protein 264

1

1

High-throughput

0.479

High

467524

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

1034268

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

0

High-throughput

0.458

High

1146309

L2GL1
Lethal(2) giant larvae protein homolog 1

1

0

High-throughput

0.458

High

1153258

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.458

High

1159701

OCLN
Occludin

1

0

High-throughput

0.458

High

1245126

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.458

High

1245079

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

2

High-throughput

0.445

High

1245089

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

3

High-throughput

0.445

High

1245091

S15A3
Solute carrier family 15 member 3

1

2

High-throughput

0.445

High

1245107

LPAR1
Lysophosphatidic acid receptor 1

1

2

High-throughput

0.445

High

76125

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

1

High-throughput

0.437

High

123257

PDLI1
PDZ and LIM domain protein 1

1

4

High-throughput

0.437

High

169604

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

3

High-throughput

0.437

High

181341

PGRC2
Membrane-associated progesterone receptor component 2

1

2

High-throughput

0.437

High

215316

TXNL1
Thioredoxin-like protein 1

1

3

High-throughput

0.437

High

289868

TIPRL
TIP41-like protein

1

1

High-throughput

0.437

High

296514

STAM2
Signal transducing adapter molecule 2

1

2

High-throughput

0.437

High

318494

TOX4
TOX high mobility group box family member 4

1

2

High-throughput

0.437

High

611182

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.437

High

775554

NU214
Nuclear pore complex protein Nup214

1

1

High-throughput

0.437

High

837674

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.437

High

854118

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.437

High

890341

NU153
Nuclear pore complex protein Nup153

1

6

High-throughput

0.437

High

890513

RBP2
E3 SUMO-protein ligase RanBP2

1

2

High-throughput

0.437

High

894834

EMD
Emerin

1

1

High-throughput

0.437

High

1013794

RL24
Large ribosomal subunit protein eL24

1

1

High-throughput

0.437

High

1132285

GOGB1
Golgin subfamily B member 1

1

1

High-throughput

0.437

High

1206835

TOIP1
Torsin-1A-interacting protein 1

1

1

High-throughput

0.437

High

1245078

LARP1
La-related protein 1

1

1

High-throughput

0.437

High

1245082

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

1

High-throughput

0.437

High

1245094

MACOI
Macoilin

1

1

High-throughput

0.437

High

1245108

STAM1
Signal transducing adapter molecule 1

1

2

High-throughput

0.437

High

1245114

EFHD2
EF-hand domain-containing protein D2

1

2

High-throughput

0.437

High

1245116

PDLI5
PDZ and LIM domain protein 5

1

3

High-throughput

0.437

High

1245128

SLK
STE20-like serine/threonine-protein kinase

1

1

High-throughput

0.437

High

1245130

GCP60
Golgi resident protein GCP60

1

1

High-throughput

0.437

High

1245131

PKHA5
Pleckstrin homology domain-containing family A member 5

1

2

High-throughput

0.437

High

1245138

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.437

High

1245141

RAI14
Ankycorbin

1

3

High-throughput

0.437

High

1245148

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

1245153

SCML2
Sex comb on midleg-like protein 2

1

1

High-throughput

0.437

High

1245155

FND3A
Fibronectin type-III domain-containing protein 3A

1

3

High-throughput

0.437

High

1245157

MAN1
Inner nuclear membrane protein Man1

1

1

High-throughput

0.437

High

1063055

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.426

High

1155068

UT2
Urea transporter 2

1

0

High-throughput

0.426

High

1245147

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.426

High

729961

1433B
14-3-3 protein beta/alpha

1

3

High-throughput

0.407

High

1245090

UBR2
E3 ubiquitin-protein ligase UBR2

1

2

High-throughput

0.407

High

1245095

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

1

High-throughput

0.407

High

1195233

TM52B
Transmembrane protein 52B

2

0

High-throughput

0.318

High

946563

EVA1C
Protein eva-1 homolog C

2

0

High-throughput

0.313

High

957763

UBE2N
Ubiquitin-conjugating enzyme E2 N

2

0

Small-scale

0.305

High

1245125

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

Small-scale

0.301

High

1245109

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

Small-scale

0.292

High

1219976

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

1245085

T200A
Transmembrane protein 200A

1

0

High-throughput

0.279

Low

1245101

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

1245103

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

0

High-throughput

0.279

Low

1245136

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

1245149

HSPB8
Heat shock protein beta-8

1

0

High-throughput

0.279

Low

334806

IPO7
Importin-7

1

0

High-throughput

0.249

Low

1103909

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

0

Small-scale

0.249

Low

1245143

F135A
Protein FAM135A

1

0

High-throughput

0.249

Low

1245159

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

Small-scale

0.249

Low

1133207

STAR3
StAR-related lipid transfer protein 3

1

0

High-throughput

0.232

Low

1211422

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.232

Low

1245098

SETD6
N-lysine methyltransferase SETD6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025