HitPredict

Interactor 1: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Interactor 2: TNR6 (P25445)
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
Gene: FAS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	18328427, 21713032
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 335
+	Hs
		522788 SRC_HUMAN (1-543): 0: 601: 74.22		TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00
+	Hs
		412024 FYN_HUMAN (1-543): 0: 582: 72.16		TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00
+	Hs
		411601 LCK_HUMAN (83-541): 0: 540: 60.78		TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00
+	Hs
		632254 BTK_HUMAN (4-537): 1.03e-165: 487: 31.35		TNR6_HUMAN (1-335): 2.61e-113: 333: 100.00
+	Hs
		522761 SRC_HUMAN (1-543): 0: 601: 74.22		TNR1A_HUMAN (22-202): 6.36e-42: 153: 20.65
+	Hs
		154294 FYN_HUMAN (1-543): 0: 582: 72.16		TR10B_HUMAN (42-216): 2.84e-31: 123: 21.91
+	Mm
		192581 LYN_MOUSE (1-541): 1.19e-179: 517: 53.14		TNR11_MOUSE (13-239): 2.89e-38: 145: 17.90
+	Mm
		591446 FYN_MOUSE (1-543): 0: 582: 71.98		TNR9_MOUSE (60-247): 1.37e-12: 68.8: 13.83
+	Mm
		411916 LCK_MOUSE (83-541): 0: 542: 60.78		TNR9_MOUSE (60-247): 1.37e-12: 68.8: 13.83
+	Mm
		648950 BTK_MOUSE (4-537): 1.92e-153: 455: 30.99		TNR5_MOUSE (31-224): 2.34e-37: 136: 20.92