Protein: LSG1
Large subunit GTPase 1 (EC 3.6.1.-)

Gene: LSG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 182
UniProt ID: P53145

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000054 - ribosomal subunit export from nucleus
GO:0003729 - mRNA binding
GO:0003924 - GTPase activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

513533

RL1A
Large ribosomal subunit protein uL1A

4

4

Small-scale

0.867

High

514323

RL12B
Large ribosomal subunit protein uL11B

3

1

High-throughput

0.817

High

806151

NMD3
60S ribosomal export protein NMD3

19

1

Small-scale

0.765

High

917710

IF6
Eukaryotic translation initiation factor 6

13

5

Small-scale

0.761

High

570082

RL3
Large ribosomal subunit protein uL3

12

3

Small-scale

0.757

High

798505

REI1
Cytoplasmic 60S subunit biogenesis factor REI1

10

2

Small-scale

0.755

High

435238

RS3
Small ribosomal subunit protein uS3

2

4

High-throughput

0.754

High

917683

ARX1
Probable metalloprotease ARX1

9

5

Small-scale

0.752

High

427370

RLA0
Large ribosomal subunit protein uL10

8

6

Small-scale

0.745

High

684789

RL5
Large ribosomal subunit protein uL18

7

5

Small-scale

0.739

High

816869

NUG1
Nuclear GTP-binding protein NUG1

2

2

Small-scale

0.737

High

835842

RL10
Large ribosomal subunit protein uL16

6

5

Small-scale

0.724

High

917676

PVH1
Tyrosine-protein phosphatase YVH1

10

0

Small-scale

0.720

High

917715

MEX67
mRNA export factor MEX67

8

0

Small-scale

0.714

High

515286

RL35A
Large ribosomal subunit protein uL29A

5

2

Small-scale

0.702

High

513726

RL2A
Large ribosomal subunit protein uL2A

4

6

High-throughput

0.676

High

917694

REH1
Cytoplasmic 60S subunit biogenesis factor REH1

4

5

Small-scale

0.669

High

917666

SDA1
Protein SDA1

3

2

High-throughput

0.662

High

864172

ALB1
Ribosome biogenesis protein ALB1

3

2

Small-scale

0.656

High

601086

RL8A
Large ribosomal subunit protein eL8A

3

6

Small-scale

0.650

High

750112

MRT4
Ribosome assembly factor MRT4

3

6

Small-scale

0.650

High

917707

YRA1
RNA annealing protein YRA1

3

2

Small-scale

0.650

High

674732

RS2
Small ribosomal subunit protein uS5

3

5

Small-scale

0.640

High

689083

RL16A
Large ribosomal subunit protein uL13A

3

6

High-throughput

0.640

High

917680

NOG1
Nucleolar GTP-binding protein 1

3

9

Small-scale

0.640

High

917696

RLP24
Ribosome biogenesis protein RLP24

3

5

Small-scale

0.633

High

885027

RL4B
Large ribosomal subunit protein uL4B

3

9

Small-scale

0.624

High

917662

LSG1
Large subunit GTPase 1

1

3

High-throughput

0.618

High

434177

RL36A
Large ribosomal subunit protein eL36A

2

3

High-throughput

0.611

High

503408

RL11A
Large ribosomal subunit protein uL5A

2

7

High-throughput

0.611

High

712622

RL8B
Large ribosomal subunit protein eL8B

2

6

High-throughput

0.611

High

482060

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

2

0

High-throughput

0.595

High

410240

RL25
Large ribosomal subunit protein uL23

2

3

High-throughput

0.584

High

433249

RL17A
Large ribosomal subunit protein uL22A

2

4

High-throughput

0.584

High

433748

RL26A
Large ribosomal subunit protein uL24A

2

6

High-throughput

0.584

High

434409

RL15A
Large ribosomal subunit protein eL15A

2

2

High-throughput

0.584

High

503816

RL27A
Large ribosomal subunit protein eL27A

2

3

High-throughput

0.584

High

511454

RL43B
Large ribosomal subunit protein eL43B

2

4

High-throughput

0.584

High

673577

NLE1
Ribosome assembly protein 4

2

7

Small-scale

0.584

High

689249

RL16B
Large ribosomal subunit protein uL13B

2

6

High-throughput

0.584

High

689563

RS7A
Small ribosomal subunit protein eS7A

2

2

High-throughput

0.584

High

792544

RL32
Large ribosomal subunit protein eL32

2

1

High-throughput

0.584

High

864478

MTR4
ATP-dependent RNA helicase DOB1

2

7

Small-scale

0.584

High

879866

RL38
Large ribosomal subunit protein eL38

2

2

High-throughput

0.584

High

917705

NOP53
Ribosome biogenesis protein NOP53

2

4

High-throughput

0.584

High

394749

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.575

High

509915

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

2

1

High-throughput

0.571

High

511581

RL44B
Large ribosomal subunit protein eL42B

2

2

Small-scale

0.571

High

531815

RL4A
Large ribosomal subunit protein uL4A

2

9

Small-scale

0.571

High

799756

IF5
Eukaryotic translation initiation factor 5

2

0

High-throughput

0.563

High

917689

CYK2
Cytokinesis protein 2

1

1

High-throughput

0.541

High

722113

XPO1
Exportin-1

1

5

High-throughput

0.536

High

917432

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

5

High-throughput

0.536

High

917667

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.536

High

917688

RRP5
rRNA biogenesis protein RRP5

1

3

High-throughput

0.536

High

818251

NSA2
Ribosome biogenesis protein NSA2

2

5

Small-scale

0.533

High

917663

CGR1
rRNA-processing protein CGR1

2

2

High-throughput

0.521

High

917684

HMO1
High mobility group protein 1

1

5

High-throughput

0.515

High

416900

CDC25
Cell division control protein 25

1

1

High-throughput

0.501

High

796788

FES1
Hsp70 nucleotide exchange factor FES1

1

0

High-throughput

0.493

High

548286

FUS1
Nuclear fusion protein FUS1

1

0

High-throughput

0.480

High

587324

ABP1
Actin-binding protein

1

0

High-throughput

0.480

High

599382

FUS3
Mitogen-activated protein kinase FUS3

1

0

High-throughput

0.480

High

917687

MYO5
Myosin-5

1

0

High-throughput

0.480

High

149866

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

154195

RL36B
Large ribosomal subunit protein eL36B

1

3

High-throughput

0.479

High

383335

RL28
Large ribosomal subunit protein uL15

1

2

High-throughput

0.479

High

383801

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.479

High

415036

RL39
Large ribosomal subunit protein eL39

1

1

High-throughput

0.479

High

432640

RL7A
Large ribosomal subunit protein uL30A

1

10

High-throughput

0.479

High

432881

RL9A
Large ribosomal subunit protein uL6A

1

3

High-throughput

0.479

High

433048

RL6B
Large ribosomal subunit protein eL6B

1

2

High-throughput

0.479

High

434052

RL33A
Large ribosomal subunit protein eL33A

1

2

High-throughput

0.479

High

434617

RL22A
Large ribosomal subunit protein eL22A

1

5

High-throughput

0.479

High

436068

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

455167

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.479

High

503148

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

503936

RL27B
Large ribosomal subunit protein eL27B

1

3

High-throughput

0.479

High

504320

RL31A
Large ribosomal subunit protein eL31A

1

6

High-throughput

0.479

High

504540

RL31B
Large ribosomal subunit protein eL31B

1

6

High-throughput

0.479

High

511236

RL20B
Large ribosomal subunit protein eL20B

1

3

High-throughput

0.479

High

512551

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.479

High

513121

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.479

High

514034

RL18B
Large ribosomal subunit protein eL18B

1

4

High-throughput

0.479

High

514738

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

515137

RL19B
Large ribosomal subunit protein eL19

1

5

High-throughput

0.479

High

569825

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.479

High

579769

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

637247

PWP1
Periodic tryptophan protein 1

1

14

Small-scale

0.479

High

663697

RL24B
Large ribosomal subunit protein eL24B

1

5

High-throughput

0.479

High

666506

DBP2
ATP-dependent RNA helicase DBP2

1

2

High-throughput

0.479

High

670944

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

679897

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

747481

RSSA1
Small ribosomal subunit protein uS2A

1

5

High-throughput

0.479

High

753482

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.479

High

778440

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

780286

EBP2
rRNA-processing protein EBP2

1

3

Small-scale

0.479

High

781226

RL14A
Large ribosomal subunit protein eL14A

1

4

High-throughput

0.479

High

792152

GBLP
Small ribosomal subunit protein RACK1

1

15

High-throughput

0.479

High

797766

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.479

High

802283

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

803413

RL14B
Large ribosomal subunit protein eL14B

1

4

High-throughput

0.479

High

812086

DHH1
ATP-dependent RNA helicase DHH1

1

7

High-throughput

0.479

High

812499

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

813707

ECM1
Shuttling pre-60S factor ECM1

1

1

High-throughput

0.479

High

817270

ARB1
ABC transporter ATP-binding protein ARB1

1

3

Small-scale

0.479

High

820920

RL13B
Large ribosomal subunit protein eL13B

1

4

High-throughput

0.479

High

825882

RL34B
Large ribosomal subunit protein eL34B

1

4

High-throughput

0.479

High

827557

RLP7
Ribosome biogenesis protein RLP7

1

10

High-throughput

0.479

High

831820

RL33B
Large ribosomal subunit protein eL33B

1

2

High-throughput

0.479

High

850109

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

3

High-throughput

0.479

High

863852

RL17B
Large ribosomal subunit protein uL22B

1

4

High-throughput

0.479

High

874427

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

879827

RL37A
Large ribosomal subunit protein eL37A

1

3

High-throughput

0.479

High

902652

RL9B
Large ribosomal subunit protein uL6B

1

3

High-throughput

0.479

High

902690

RL37B
Large ribosomal subunit protein eL37B

1

3

High-throughput

0.479

High

917664

RL26B
Large ribosomal subunit protein uL24B

1

6

High-throughput

0.479

High

917665

PESC
Pescadillo homolog

1

2

High-throughput

0.479

High

917668

JJJ1
J protein JJJ1

1

11

High-throughput

0.479

High

917669

RL22B
Large ribosomal subunit protein eL22B

1

5

High-throughput

0.479

High

917670

RL34A
Large ribosomal subunit protein eL34A

1

4

High-throughput

0.479

High

917673

CDC14
Tyrosine-protein phosphatase CDC14

1

5

High-throughput

0.479

High

917674

NOP3
Serine/arginine

1

9

High-throughput

0.479

High

917675

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

917677

RL6A
Large ribosomal subunit protein eL6A

1

2

High-throughput

0.479

High

917678

RL21A
Large ribosomal subunit protein eL21A

1

2

High-throughput

0.479

High

917681

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

917686

VMS1
tRNA endonuclease VMS1

1

4

High-throughput

0.479

High

917692

NOC4
Nucleolar complex protein 4

1

9

High-throughput

0.479

High

917695

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.479

High

917697

BUD20
Bud site selection protein 20

1

2

Small-scale

0.479

High

917699

SGO1
Shugoshin

1

2

High-throughput

0.479

High

917702

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

917708

RL7B
Large ribosomal subunit protein uL30B

1

10

High-throughput

0.479

High

917711

RQC2
Ribosome quality control complex subunit 2

1

1

High-throughput

0.479

High

917712

RL21B
Large ribosomal subunit protein eL21B

1

2

High-throughput

0.479

High

917713

RL13A
Large ribosomal subunit protein eL13A

1

4

High-throughput

0.479

High

917714

RL11B
Large ribosomal subunit protein uL5B

1

7

High-throughput

0.479

High

917682

HAS1
ATP-dependent RNA helicase HAS1

1

19

High-throughput

0.470

High

917703

RRS1
Regulator of ribosome biosynthesis

1

4

High-throughput

0.470

High

383163

RLA4
Large ribosomal subunit protein P2B

1

0

High-throughput

0.458

High

427590

RLA1
Large ribosomal subunit protein P1A

1

0

High-throughput

0.458

High

434266

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

511683

RS23B
Small ribosomal subunit protein uS12B

1

0

High-throughput

0.458

High

515376

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.458

High

917679

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

917690

RQC1
Ribosome quality control complex subunit 1

1

0

High-throughput

0.458

High

506511

YL016
Putative truncated guanine nucleotide exchange factor SDC25

1

1

High-throughput

0.457

High

917700

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.457

High

510660

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.445

High

524618

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

545634

SSB1
Ribosome-associated molecular chaperone SSB1

1

9

High-throughput

0.445

High

626822

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.445

High

752528

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

804313

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.445

High

805000

IPI1
Pre-rRNA-processing protein IPI1

1

2

Small-scale

0.445

High

819317

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

863663

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.445

High

917672

SEN1
Helicase SEN1

1

1

Small-scale

0.445

High

647170

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.437

High

677490

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

707700

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

781633

DBP7
ATP-dependent RNA helicase DBP7

1

16

High-throughput

0.437

High

793501

MAK5
ATP-dependent RNA helicase MAK5

1

17

High-throughput

0.437

High

795111

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

844542

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.437

High

865678

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

917671

NUM1
Nuclear migration protein NUM1

1

3

High-throughput

0.437

High

917685

DHR1
Probable ATP-dependent RNA helicase DHR1

1

5

High-throughput

0.437

High

917691

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

917693

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.437

High

917698

NOP12
Nucleolar protein 12

1

7

High-throughput

0.437

High

917701

TMA16
Translation machinery-associated protein 16

1

2

High-throughput

0.437

High

917704

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

917709

DBP10
ATP-dependent RNA helicase DBP10

1

11

High-throughput

0.437

High

450615

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.426

High

381180

H2B1
Histone H2B.1

1

6

High-throughput

0.407

High

823623

TCPE
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.407

High

758042

MTR2
mRNA transport regulator MTR2

4

0

Small-scale

0.354

High

877863

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

917706

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025