HitPredict

Interactor 1: IGF1R (P08069)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: HYOU1 (Q9Y4L1)
Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Gene: HYOU1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1367 Hs			1 999
+	Hs
		320797 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		411535 INSR_HUMAN (32-1365): 0: 1219: 56.54		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		411458 INSR_HUMAN (32-1365): 0: 1219: 56.54		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320795 INSR_HUMAN (32-1365): 0: 1219: 56.54		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		435511 IGF1R_HUMAN (1-1367): 0: 1387: 100.00		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		665546 EPHA8_HUMAN (655-1337): 4.83e-169: 533: 23.87		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		1072565 EPHA7_HUMAN (656-1342): 1.15e-177: 555: 23.39		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		665505 EPHA8_HUMAN (655-1337): 4.83e-169: 533: 23.87		HS105_HUMAN (33-960): 0: 812: 24.46
+	Rn
		544811 INSR_RAT (20-1365): 0: 1210: 55.45		HSP7C_RAT (682-815): 1.96e-30: 130: 16.42
+	Hs
		320817 EPHA8_HUMAN (655-1337): 4.83e-169: 533: 23.87		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		1357278 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		666667 LTK_HUMAN (989-1319): 5.64e-75: 270: 40.11		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		1267783 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320928 ALK_HUMAN (939-1304): 2.51e-75: 278: 39.12		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		385266 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320790 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		384373 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		384372 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		HS71L_HUMAN (682-814): 9.92e-31: 131: 15.04
+	Hs
		384163 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		384219 NTRK1_HUMAN (977-1262): 3.02e-70: 254: 42.61		HSP76_HUMAN (682-813): 1.1e-27: 121: 19.70