HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 976
+	Hs
		431561 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		438029 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		438028 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB1_HUMAN (27-973): 0: 1106: 47.26
+	Hs
		437892 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA1_HUMAN (17-967): 0: 959: 49.38
+	Hs
		431531 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHA1_HUMAN (17-967): 0: 959: 49.38
+	Hs
		171281 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB6_HUMAN (28-962): 0: 871: 37.66
+	Hs
		171280 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHB6_HUMAN (28-962): 0: 871: 37.66
+	Hs
		437855 HS90B_HUMAN (1-724): 0: 1086: 100.00		INSRR_HUMAN (287-911): 2.3e-146: 470: 27.55
+	Hs
		438114 HS90B_HUMAN (1-724): 0: 1086: 100.00		MERTK_HUMAN (270-900): 9.58e-146: 460: 23.90
+	Hs
		437923 HS90B_HUMAN (1-724): 0: 1086: 100.00		UFO_HUMAN (294-911): 1.98e-146: 459: 24.49
+	Hs
		431488 HS90A_HUMAN (1-724): 0: 1072: 85.25		INSRR_HUMAN (287-911): 2.3e-146: 470: 27.55
+	Hs
		435497 HS90B_HUMAN (1-724): 0: 1086: 100.00		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		437897 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		431438 HS90A_HUMAN (1-724): 0: 1072: 85.25		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		431536 HS90A_HUMAN (1-724): 0: 1072: 85.25		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		437817 HS90B_HUMAN (1-724): 0: 1086: 100.00		HCK_HUMAN (591-880): 1.46e-65: 231: 42.12
+	Hs
		433526 HS90B_HUMAN (1-724): 0: 1086: 100.00		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		437967 HS90B_HUMAN (1-724): 0: 1086: 100.00		FRK_HUMAN (525-864): 4.94e-64: 226: 37.46
+	Hs
		431445 HS90A_HUMAN (1-724): 0: 1072: 85.25		HCK_HUMAN (591-880): 1.46e-65: 231: 42.12
+	Hs
		431434 HS90A_HUMAN (1-724): 0: 1072: 85.25		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91