Protein: KLHL4
Kelch-like protein 4

Gene: KLHL4
Organism: Homo sapiens
Interactions: 37
UniProt ID: Q9C0H6

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005737 - cytoplasm
GO:0005929 - cilium
GO:0015630 - microtubule cytoskeleton
GO:0031463 - Cul3-RING ubiquitin ligase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114239

CUL3
Cullin-3

4

20

Small-scale

0.881

High

1399934

KLHL5
Kelch-like protein 5

2

18

High-throughput

0.737

High

1421276

KLHL1
Kelch-like protein 1

2

20

High-throughput

0.737

High

1421279

GIT1
ARF GTPase-activating protein GIT1

1

5

High-throughput

0.648

High

1421275

KLHL4
Kelch-like protein 4

1

19

High-throughput

0.618

High

1112703

CUL1
Cullin-1

1

20

High-throughput

0.575

High

1122439

GIT2
ARF GTPase-activating protein GIT2

1

5

High-throughput

0.553

High

249195

DSCAM
Cell adhesion molecule DSCAM

1

2

High-throughput

0.494

High

404399

GCR
Glucocorticoid receptor

1

4

High-throughput

0.479

High

908168

KS6A3
Ribosomal protein S6 kinase alpha-3

1

5

High-throughput

0.479

High

958710

CSN2
COP9 signalosome complex subunit 2

1

20

High-throughput

0.479

High

1094414

CSN1
COP9 signalosome complex subunit 1

1

16

High-throughput

0.479

High

1096496

PAK1
Serine/threonine-protein kinase PAK 1

1

9

High-throughput

0.479

High

1121981

ARHG7
Rho guanine nucleotide exchange factor 7

1

6

High-throughput

0.479

High

1133170

LASP1
LIM and SH3 domain protein 1

1

7

High-throughput

0.479

High

1140195

ARHG6
Rho guanine nucleotide exchange factor 6

1

6

High-throughput

0.479

High

1245061

TRI65
E3 ubiquitin-protein ligase TRIM65

1

3

High-throughput

0.479

High

1272553

CSN6
COP9 signalosome complex subunit 6

1

11

High-throughput

0.479

High

1308583

NUDC3
NudC domain-containing protein 3

1

20

High-throughput

0.479

High

1352154

DYH5
Dynein axonemal heavy chain 5

1

1

High-throughput

0.479

High

1358106

NUDC2
NudC domain-containing protein 2

1

20

High-throughput

0.479

High

1370358

CSN5
COP9 signalosome complex subunit 5

1

12

High-throughput

0.479

High

1406125

CSN8
COP9 signalosome complex subunit 8

1

3

High-throughput

0.479

High

1421278

CSN3
COP9 signalosome complex subunit 3

1

19

High-throughput

0.479

High

1421280

ARI1
E3 ubiquitin-protein ligase ARIH1

1

14

High-throughput

0.479

High

414572

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

446036

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

1421277

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

551917

CO6A3

1

11

High-throughput

0.437

High

878556

PAXI
Paxillin

1

4

High-throughput

0.437

High

1206139

TGO1
Transport and Golgi organization protein 1 homolog

1

4

High-throughput

0.437

High

1216560

VP13D
Intermembrane lipid transfer protein VPS13D

1

1

High-throughput

0.437

High

1338702

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

7

High-throughput

0.437

High

1353757

SHRM3
Protein Shroom3

1

4

High-throughput

0.437

High

249365

PLXC1
Plexin-C1

1

0

High-throughput

0.249

Low

1215927

OGRL1
Opioid growth factor receptor-like protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025