HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 583
+	Hs
		431563 HS90A_HUMAN (1-724): 0: 1072: 85.25		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		437817 HS90B_HUMAN (1-724): 0: 1086: 100.00		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		437867 HS90B_HUMAN (1-724): 0: 1086: 100.00		FER_HUMAN (345-581): 6.27e-42: 163: 18.75
+	Hs
		438012 HS90B_HUMAN (1-724): 0: 1086: 100.00		BMX_HUMAN (341-582): 1.11e-38: 153: 19.69
+	Hs
		426937 HS90B_HUMAN (1-724): 0: 1086: 100.00		FES_HUMAN (326-581): 1.46e-37: 150: 21.79
+	Hs
		431445 HS90A_HUMAN (1-724): 0: 1072: 85.25		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		431507 HS90A_HUMAN (1-724): 0: 1072: 85.25		FER_HUMAN (345-581): 6.27e-42: 163: 18.75
+	Hs
		431673 HS90A_HUMAN (1-724): 0: 1072: 85.25		BMX_HUMAN (341-582): 1.11e-38: 153: 19.69
+	Hs
		426936 HS90A_HUMAN (1-724): 0: 1072: 85.25		FES_HUMAN (326-581): 1.46e-37: 150: 21.79
+	Rn
		948942 HS90A_RAT (1-724): 0: 1070: 84.45		GRB7_RAT (371-563): 1.44e-37: 148: 22.06
+	Dm
		365472 HSP83_DROME (10-724): 0: 1057: 78.46		SRC42_DROME (351-579): 6.25e-40: 154: 18.07
+	Hs
		129168 HS90A_HUMAN (1-724): 0: 1072: 85.25		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		438060 HS90B_HUMAN (1-724): 0: 1086: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		431723 HS90A_HUMAN (1-724): 0: 1072: 85.25		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Dm
		365439 HSP83_DROME (10-724): 0: 1057: 78.46		CSW_DROME (483-579): 2.71e-12: 71.8: 27.72
+	Hs
		442841 H90B3_HUMAN (1-724): 0: 815: 75.83		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		850745 H90B3_HUMAN (1-724): 0: 815: 75.83		BMX_HUMAN (341-582): 1.11e-38: 153: 19.69