HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: CLK3 (P49761)
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
Gene: CLK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 32707033, 22939624
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 638
+	Hs
		431656 HS90A_HUMAN (1-724): 0: 1072: 85.25		CLK3_HUMAN (1-638): 0: 542: 100.00
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26
+	Hs
		437996 HS90B_HUMAN (1-724): 0: 1086: 100.00		CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26
+	Hs
		431655 HS90A_HUMAN (1-724): 0: 1072: 85.25		CLK2_HUMAN (149-638): 5.31e-135: 406: 58.52
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK3_HUMAN (301-632): 2.49e-129: 384: 23.89
+	Hs
		438155 HS90B_HUMAN (1-724): 0: 1086: 100.00		DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (301-632): 2.49e-129: 384: 23.89
+	Hs
		431834 HS90A_HUMAN (1-724): 0: 1072: 85.25		DYR1A_HUMAN (181-637): 4.69e-123: 384: 26.20
+	Hs
		438406 HS90B_HUMAN (1-724): 0: 1086: 100.00		DYRK2_HUMAN (93-633): 2.19e-117: 364: 23.45
+	Hs
		438553 HS90B_HUMAN (1-724): 0: 1086: 100.00		DYRK4_HUMAN (199-637): 3.87e-116: 358: 25.74
+	Hs
		432121 HS90A_HUMAN (1-724): 0: 1072: 85.25		DYRK2_HUMAN (93-633): 2.19e-117: 364: 23.45
+	Hs
		438648 HS90B_HUMAN (1-724): 0: 1086: 100.00		DYR1B_HUMAN (210-633): 7.87e-110: 345: 26.85
+	Hs
		432288 HS90A_HUMAN (1-724): 0: 1072: 85.25		DYRK4_HUMAN (199-637): 3.87e-116: 358: 25.74
+	Hs
		414683 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK1_HUMAN (301-624): 5.68e-119: 357: 24.70
+	Hs
		432392 HS90A_HUMAN (1-724): 0: 1072: 85.25		DYR1B_HUMAN (210-633): 7.87e-110: 345: 26.85
+	Hs
		834058 H90B3_HUMAN (1-724): 0: 815: 75.83		CLK3_HUMAN (1-638): 0: 542: 100.00
+	Hs
		538107 ENPL_HUMAN (3-693): 0: 917: 46.44		CDK2_HUMAN (301-631): 4.28e-138: 406: 24.26
+	Sp
		383458 HSP90_SCHPO (10-724): 0: 929: 62.48		CDK1_SCHPO (301-624): 3.89e-118: 355: 23.05
+	Hs
		834057 H90B4_HUMAN (25-596): 0: 639: 71.85		CLK3_HUMAN (1-638): 0: 542: 100.00