Protein: OTC
Ornithine transcarbamylase, mitochondrial (OTCase) (EC 2.1.3.3) (Ornithine carbamoyltransferase, mitochondrial)

Gene: OTC
Organism: Homo sapiens
Interactions: 103
UniProt ID: P00480

Gene Ontology (top 5):
GO:0000050 - urea cycle
GO:0001889 - liver development
GO:0004585 - ornithine carbamoyltransferase activity
GO:0005543 - phospholipid binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

361602

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

2

1

High-throughput

0.628

High

361654

SYNM
Asparaginyl-tRNA synthetase

2

3

High-throughput

0.628

High

322181

GLSK
Glutaminase kidney isoform, mitochondrial

2

2

High-throughput

0.611

High

361620

DPOG1
DNA polymerase subunit gamma-1

2

0

High-throughput

0.602

High

361640

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

2

0

High-throughput

0.585

High

361660

TBB1
Tubulin beta-1 chain

2

3

High-throughput

0.574

High

361608

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

4

High-throughput

0.536

High

361615

SYHM
Histidine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

361655

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

High-throughput

0.536

High

361664

NPS3A
Protein NipSnap homolog 3A

1

1

High-throughput

0.536

High

361644

NDUF7
Protein arginine methyltransferase NDUFAF7, mitochondrial

1

0

High-throughput

0.513

High

361598

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.494

High

361634

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

Small-scale

0.480

High

61390

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

301831

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

1

High-throughput

0.479

High

359560

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

2

High-throughput

0.479

High

361595

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.479

High

361596

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.479

High

361597

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

2

High-throughput

0.479

High

361609

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

1

High-throughput

0.479

High

361611

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.479

High

361614

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

361616

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

1

High-throughput

0.479

High

361619

RM12
Large ribosomal subunit protein bL12m

1

1

High-throughput

0.479

High

361622

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

1

High-throughput

0.479

High

361625

RT10
Small ribosomal subunit protein uS10m

1

1

High-throughput

0.479

High

361627

RT05
Small ribosomal subunit protein uS5m

1

2

High-throughput

0.479

High

361632

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

2

High-throughput

0.479

High

361633

SYLM
Leucine--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

361639

SYVM
Valine--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

361645

ACOT1
Acyl-coenzyme A thioesterase 1

1

1

High-throughput

0.479

High

361650

P5CR2
Pyrroline-5-carboxylate reductase 2

1

1

High-throughput

0.479

High

361661

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

361671

RT02
Small ribosomal subunit protein uS2m

1

3

High-throughput

0.479

High

361676

NFS1
Cysteine desulfurase

1

1

High-throughput

0.479

High

71688

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

0

High-throughput

0.458

High

127445

NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

1

0

High-throughput

0.458

High

143779

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

0

High-throughput

0.458

High

177504

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.458

High

209727

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.458

High

221494

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.458

High

223782

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.458

High

256221

RT14
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.458

High

275226

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.458

High

275594

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.458

High

278603

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.458

High

283754

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

328485

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.458

High

329196

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.458

High

361594

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

0

High-throughput

0.458

High

361599

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

361600

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.458

High

361601

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.458

High

361603

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.458

High

361604

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

0

High-throughput

0.458

High

361605

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.458

High

361606

ECHM
Enoyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

361607

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

1

0

High-throughput

0.458

High

361610

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

361612

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.458

High

361613

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

361617

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.458

High

361618

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.458

High

361621

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.458

High

361623

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.458

High

361624

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.458

High

361626

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.458

High

361628

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

0

High-throughput

0.458

High

361629

RT34
Small ribosomal subunit protein mS34

1

0

High-throughput

0.458

High

361630

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.458

High

361631

RT09
Small ribosomal subunit protein uS9m

1

0

High-throughput

0.458

High

361635

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.458

High

361636

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.458

High

361637

PPCEL
Prolyl endopeptidase-like

1

0

High-throughput

0.458

High

361638

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.458

High

361643

TM10C
tRNA methyltransferase 10 homolog C

1

0

High-throughput

0.458

High

361646

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

1

0

High-throughput

0.458

High

361647

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

1

0

High-throughput

0.458

High

361648

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.458

High

361649

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.458

High

361651

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

361652

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.458

High

361653

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.458

High

361656

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

0

High-throughput

0.458

High

361657

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

361658

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

361659

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.458

High

361662

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.458

High

361663

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

0

High-throughput

0.458

High

361665

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.458

High

361666

STML2
Stomatin-like protein 2, mitochondrial

1

0

High-throughput

0.458

High

361667

RT28
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.458

High

361668

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.458

High

361669

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.458

High

361670

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.458

High

361672

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.458

High

361673

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.458

High

361674

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.458

High

361675

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.458

High

67345

RTL8C
Retrotransposon Gag-like protein 8C

2

0

High-throughput

0.328

High

361641

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.249

Low

361642

POTEE
POTE ankyrin domain family member E

1

0

High-throughput

0.249

Low

361677

PCLO
Protein piccolo

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025