HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: SGK2 (Q9HBY8)
Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2)
Gene: SGK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	33961781, 32707033, 22939624
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 367
+	Hs
		437907 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCL_HUMAN (13-363): 1.31e-151: 444: 41.64
+	Hs
		116958 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK1_HUMAN (3-365): 9.63e-154: 441: 68.73
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (5-359): 4.08e-153: 441: 47.06
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (6-359): 1.54e-151: 437: 47.90
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (6-359): 7.17e-152: 438: 47.62
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (6-359): 3.45e-151: 436: 47.62
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (1-359): 6.48e-151: 436: 47.66
+	Hs
		438085 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCE_HUMAN (6-362): 3.33e-146: 432: 41.67
+	Hs
		438094 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCT_HUMAN (24-365): 1.64e-146: 432: 40.06
+	Hs
		116956 HS90A_HUMAN (1-724): 0: 1072: 85.25		SGK1_HUMAN (3-365): 9.63e-154: 441: 68.73
+	Hs
		438422 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK3_HUMAN (9-364): 7.87e-146: 423: 67.69
+	Hs
		438585 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B2_HUMAN (27-361): 4.56e-146: 423: 45.29
+	Hs
		437905 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B1_HUMAN (4-361): 3.11e-145: 422: 42.15
+	Hs
		438011 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A3_HUMAN (25-335): 1.1e-104: 325: 25.47
+	Hs
		438193 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A1_HUMAN (13-338): 1.87e-104: 325: 25.52
+	Hs
		438190 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A2_HUMAN (7-335): 7.98e-102: 318: 25.88
+	Hs
		270364 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A5_HUMAN (12-294): 6.28e-99: 312: 26.17
+	Hs
		437962 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCI_HUMAN (34-340): 2.85e-99: 307: 46.23
+	Hs
		438097 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCZ_HUMAN (34-357): 1.99e-96: 300: 45.21
+	Hs
		270363 HS90A_HUMAN (1-724): 0: 1072: 85.25		KS6A5_HUMAN (12-294): 6.28e-99: 312: 26.17