Protein: UB2E2
Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)

Gene: UB2E2, UBE2E2
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q96LR5

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006513 - protein monoubiquitination
GO:0006974 - DNA damage response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1391011

OTUB1
Ubiquitin thioesterase OTUB1

6

11

High-throughput

0.944

High

647626

UBA1
Ubiquitin-like modifier-activating enzyme 1

5

19

Small-scale

0.917

High

1397287

RNF5
E3 ubiquitin-protein ligase RNF5

4

20

High-throughput

0.911

High

1384575

RNF25
E3 ubiquitin-protein ligase RNF25

4

14

High-throughput

0.903

High

302613

RNF8
E3 ubiquitin-protein ligase RNF8

4

20

Small-scale

0.888

High

1294552

DZIP3
E3 ubiquitin-protein ligase DZIP3

4

20

High-throughput

0.885

High

242616

PRKN
E3 ubiquitin-protein ligase parkin

4

20

Small-scale

0.878

High

1397296

RNF12
E3 ubiquitin-protein ligase RLIM

3

20

Small-scale

0.868

High

186577

TRI18
E3 ubiquitin-protein ligase Midline-1

7

20

Small-scale

0.865

High

799401

BRCA1
Breast cancer type 1 susceptibility protein

3

20

Small-scale

0.865

High

1397300

RNF14
E3 ubiquitin-protein ligase RNF14

3

20

Small-scale

0.861

High

1389445

CHFR
E3 ubiquitin-protein ligase CHFR

3

20

High-throughput

0.861

High

1397285

RING2
E3 ubiquitin-protein ligase RING2

3

20

High-throughput

0.861

High

1394586

ITCH
E3 ubiquitin-protein ligase Itchy homolog

3

20

Small-scale

0.858

High

1028344

MDM2
E3 ubiquitin-protein ligase Mdm2

3

13

Small-scale

0.845

High

1397302

HERC5
E3 ISG15--protein ligase HERC5

3

20

Small-scale

0.829

High

1397303

TRIM1
Probable E3 ubiquitin-protein ligase MID2

4

20

Small-scale

0.808

High

1004983

RNF4
E3 ubiquitin-protein ligase RNF4

2

20

Small-scale

0.800

High

1252767

RN111
E3 ubiquitin-protein ligase Arkadia

2

20

High-throughput

0.800

High

1397292

TRIM2
Tripartite motif-containing protein 2

2

20

Small-scale

0.800

High

1055842

RING1
E3 ubiquitin-protein ligase RING1

2

20

High-throughput

0.791

High

1336242

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

2

20

High-throughput

0.791

High

132240

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

20

High-throughput

0.783

High

279067

TRIM3
Tripartite motif-containing protein 3

2

20

High-throughput

0.783

High

1397307

RN115
E3 ubiquitin-protein ligase RNF115

2

20

High-throughput

0.783

High

1397280

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

17

Small-scale

0.778

High

1397304

CHIP
E3 ubiquitin-protein ligase CHIP

2

15

Small-scale

0.778

High

1391908

RN185
E3 ubiquitin-protein ligase RNF185

3

20

High-throughput

0.770

High

1093402

TRI32
E3 ubiquitin-protein ligase TRIM32

2

20

Small-scale

0.767

High

1294325

TRI50
E3 ubiquitin-protein ligase TRIM50

3

20

Small-scale

0.755

High

128514

RN103
E3 ubiquitin-protein ligase RNF103

2

20

Small-scale

0.754

High

1397295

TRI39
E3 ubiquitin-protein ligase TRIM39

6

20

High-throughput

0.738

High

1389538

RN125
E3 ubiquitin-protein ligase RNF125

2

20

Small-scale

0.726

High

322560

RNF37
RING finger protein 37

1

5

High-throughput

0.698

High

335167

ARI2
E3 ubiquitin-protein ligase ARIH2

1

20

High-throughput

0.698

High

766112

PCGF2
Polycomb group RING finger protein 2

1

20

High-throughput

0.698

High

783375

TRI23
E3 ubiquitin-protein ligase TRIM23

1

7

High-throughput

0.698

High

1022776

XIAP
E3 ubiquitin-protein ligase XIAP

1

20

High-throughput

0.698

High

1093691

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

14

High-throughput

0.698

High

1328515

RNF10
E3 ubiquitin-protein ligase RNF10

1

20

High-throughput

0.698

High

1350942

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

20

High-throughput

0.698

High

1397305

RNF11
RING finger protein 11

1

20

High-throughput

0.698

High

1397309

RN114
E3 ubiquitin-protein ligase RNF114

1

20

High-throughput

0.698

High

1340782

COP1
E3 ubiquitin-protein ligase COP1

1

10

High-throughput

0.691

High

983937

RBX1
E3 ubiquitin-protein ligase RBX1

1

20

Small-scale

0.647

High

1114027

CUL3
Cullin-3

1

16

Small-scale

0.647

High

1315650

RN168
E3 ubiquitin-protein ligase RNF168

1

7

Small-scale

0.647

High

1389348

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.647

High

1397281

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

Small-scale

0.647

High

1397308

ARI1
E3 ubiquitin-protein ligase ARIH1

1

20

Small-scale

0.647

High

1272661

DET1
DET1 homolog

2

3

High-throughput

0.628

High

1397306

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

2

High-throughput

0.628

High

1331911

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

20

High-throughput

0.625

High

1382333

RN166
E3 ubiquitin-protein ligase RNF166

1

20

High-throughput

0.625

High

1307769

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

20

Small-scale

0.624

High

651408

CBL
E3 ubiquitin-protein ligase CBL

1

12

Small-scale

0.621

High

1340067

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

20

Small-scale

0.621

High

1381388

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

20

Small-scale

0.621

High

1397288

RN126
E3 ubiquitin-protein ligase RNF126

1

20

High-throughput

0.621

High

1397293

TRI45
E3 ubiquitin-protein ligase TRIM45

1

20

Small-scale

0.621

High

508456

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.618

High

1397290

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

20

High-throughput

0.618

High

1397299

DTL
Denticleless protein homolog

1

9

Small-scale

0.618

High

1384106

ARRD3
Arrestin domain-containing protein 3

3

7

High-throughput

0.616

High

1156697

NF2L2
Nuclear factor erythroid 2-related factor 2

2

3

Small-scale

0.595

High

325987

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.590

High

1217715

RN220
E3 ubiquitin-protein ligase RNF220

1

7

High-throughput

0.590

High

1397301

IPO11
Importin-11

1

3

Small-scale

0.579

High

1139117

DAZP2
DAZ-associated protein 2

1

2

High-throughput

0.573

High

1397297

CUED1
CUE domain-containing protein 1

2

2

High-throughput

0.553

High

1397298

PGPI
Pyroglutamyl-peptidase 1

2

1

High-throughput

0.553

High

1006633

SRPK2
SRSF protein kinase 2

1

7

High-throughput

0.550

High

1397283

SRPK1
SRSF protein kinase 1

1

9

High-throughput

0.550

High

1397284

MINT
Msx2-interacting protein

1

0

Small-scale

0.549

High

1316963

FAM9B
Protein FAM9B

1

0

High-throughput

0.549

High

1288119

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

20

High-throughput

0.541

High

1055259

MTG8
Protein CBFA2T1

1

0

Small-scale

0.537

High

1397282

PRAM
PML-RARA-regulated adapter molecule 1

1

2

Small-scale

0.512

High

1100252

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.501

High

1397286

BARD1
BRCA1-associated RING domain protein 1

1

10

Small-scale

0.501

High

142698

TRI38
E3 ubiquitin-protein ligase TRIM38

1

20

Small-scale

0.481

High

323533

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

Small-scale

0.481

High

572141

TRI27
Zinc finger protein RFP

1

20

Small-scale

0.481

High

1397291

TRI31
E3 ubiquitin-protein ligase TRIM31

1

20

Small-scale

0.481

High

1395578

PDLI2
PDZ and LIM domain protein 2

1

0

Small-scale

0.480

High

1368058

HDAC2
Histone deacetylase 2

1

3

Small-scale

0.479

High

422907

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

1260614

ASXL2
Putative Polycomb group protein ASXL2

1

3

Small-scale

0.457

High

1397294

RC3H2
Roquin-2

1

7

Small-scale

0.457

High

1287251

TBCD1
TBC1 domain family member 1

1

1

High-throughput

0.457

High

358779

LDHA
L-lactate dehydrogenase A chain

1

0

High-throughput

0.438

High

1108049

SQSTM
Sequestosome-1

1

18

High-throughput

0.437

High

1397289

DDA1
DET1- and DDB1-associated protein 1

1

2

Small-scale

0.437

High


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Last updated: 11Aug2025