HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: CHRD1 (Q9UHD1)
Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana)
Gene: CHORDC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.933

Property	Details
Experiments	32296183, 26496610, 23414517, 25036637, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CHORD~HSP90
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 332
+	Mm
		513702 HS90B_MOUSE (1-724): 0: 1089: 99.59		CHRD1_MOUSE (1-328): 5.56e-174: 487: 96.34
+	Hs
		111942 K9JA46_HUMAN (1-724): 0: 1072: 85.25		CHRD1_HUMAN (1-332): 4.52e-177: 495: 100.00
+	Hs
		432333 HS90A_HUMAN (1-724): 0: 1072: 85.25		CHRD1_HUMAN (1-332): 4.52e-177: 495: 100.00
+	Mm
		432455 HS90A_MOUSE (1-724): 0: 1068: 84.31		CHRD1_MOUSE (1-328): 5.56e-174: 487: 96.34
+	Mm
		513706 HS90B_MOUSE (1-724): 0: 1089: 99.59		ITBP2_MOUSE (1-326): 6.8e-155: 439: 48.33
+	Hs
		438609 HS90B_HUMAN (1-724): 0: 1086: 100.00		ITBP2_HUMAN (1-326): 6.98e-155: 439: 46.95
+	Hs
		432350 HS90A_HUMAN (1-724): 0: 1072: 85.25		ITBP2_HUMAN (1-326): 6.98e-155: 439: 46.95
+	Mm
		432458 HS90A_MOUSE (1-724): 0: 1068: 84.31		ITBP2_MOUSE (1-326): 6.8e-155: 439: 48.33
+	Dm
		365474 HSP83_DROME (10-724): 0: 1057: 78.46		CHRD1_DROME (4-332): 5.64e-145: 414: 42.18
+	Hs
		438644 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGT1_HUMAN (173-332): 1.99e-46: 162: 18.14
+	Hs
		432387 HS90A_HUMAN (1-724): 0: 1072: 85.25		SGT1_HUMAN (173-332): 1.99e-46: 162: 18.14
+	At
		646596 HS901_ARATH (10-724): 0: 999: 67.97		SGT1A_ARATH (220-332): 3.14e-39: 143: 24.78
+	At
		878286 HS902_ARATH (10-724): 0: 1003: 66.85		SGT1B_ARATH (230-331): 1.21e-35: 134: 28.43
+	At
		646597 HS901_ARATH (10-724): 0: 999: 67.97		SGT1B_ARATH (230-331): 1.21e-35: 134: 28.43
+	At
		878285 HS902_ARATH (10-724): 0: 1003: 66.85		RAR1_ARATH (157-229): 7.41e-17: 80.3: 36.99
+	At
		646595 HS901_ARATH (10-724): 0: 999: 67.97		RAR1_ARATH (157-229): 7.41e-17: 80.3: 36.99
+	Hs
		538450 ENPL_HUMAN (3-693): 0: 917: 46.44		SGT1_HUMAN (173-332): 1.99e-46: 162: 18.14
+	Sc
		367015 HSP82_YEAST (12-724): 0: 927: 61.26		SGT1_YEAST (213-329): 7.9e-27: 111: 22.14
+	Sc
		544530 HSC82_YEAST (13-724): 0: 922: 60.22		SGT1_YEAST (213-329): 7.9e-27: 111: 22.14
+	Hs
		73149 Q6PK50_HUMAN (1-350): 0: 618: 99.71		B4DYC6_HUMAN (173-332): 1.36e-51: 173: 21.21