HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36199071, 22939624
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0046983 - protein dimerization activity GO:0051726 - regulation of cell cycle
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 605
+	Hs
		432379 HS90A_HUMAN (1-724): 0: 1072: 85.25		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		438606 HS90B_HUMAN (1-724): 0: 1086: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		432348 HS90A_HUMAN (1-724): 0: 1072: 85.25		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		438414 HS90B_HUMAN (1-724): 0: 1086: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		432132 HS90A_HUMAN (1-724): 0: 1072: 85.25		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		437971 HS90B_HUMAN (1-724): 0: 1086: 100.00		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		431630 HS90A_HUMAN (1-724): 0: 1072: 85.25		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		438048 HS90B_HUMAN (1-724): 0: 1086: 100.00		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		538344 ENPL_HUMAN (3-693): 0: 917: 46.44		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		538141 ENPL_HUMAN (3-693): 0: 917: 46.44		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		538184 ENPL_HUMAN (3-693): 0: 917: 46.44		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Sc
		366295 HSP82_YEAST (12-724): 0: 927: 61.26		MET30_YEAST (530-604): 1.34e-09: 63.1: 20.00
+	Hs
		1162508 Q6PK50_HUMAN (1-350): 0: 618: 99.71		Q86WI5_HUMAN (1-103): 2.61e-42: 148: 74.76