HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 1290
+	Hs
		441423 MET_HUMAN (1-1390): 0: 1283: 100.00		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Hs
		580981 RON_HUMAN (23-1390): 0: 934: 32.70		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		580965 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		580937 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		562635 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Hs
		580927 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		580923 FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Mm
		555055 MET_MOUSE (1-1381): 0: 1246: 89.57		PLCB1_MOUSE (713-1287): 1.66e-90: 321: 21.31
+	Hs
		195967 PLXB1_HUMAN (464-1030): 8.24e-66: 248: 20.88		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		580942 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		165159 PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		411292 INSR_HUMAN (1084-1335): 3.87e-55: 213: 42.11		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		581010 ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Hs
		337341 ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38		PLCG1_HUMAN (1-1290): 0: 1314: 100.00
+	Rn
		499158 INSR_RAT (1084-1335): 3.22e-52: 204: 40.98		PLCG1_RAT (1-1290): 0: 1299: 96.90
+	Mm
		1141452 MERTK_MOUSE (1057-1378): 2.2e-66: 246: 40.53		PLCG2_MOUSE (19-1287): 0: 1131: 50.12
+	Hs
		195966 PLXB1_HUMAN (464-1030): 8.24e-66: 248: 20.88		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Hs
		562648 ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75		PLCG2_HUMAN (18-1287): 0: 1128: 49.45
+	Hs
		609614 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		PLCL2_HUMAN (840-1240): 4.61e-92: 324: 29.23
+	Hs
		537758 INSRR_HUMAN (1056-1337): 6.24e-54: 209: 39.67		PLCD3_HUMAN (735-1214): 3.7e-87: 303: 27.27